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Psychological factors associated with foot and ankle pain: a mixed methods systematic review
Journal of Foot and Ankle Research volume 15, Article number: 10 (2022)
Foot and ankle pain is common, and generally viewed through a biomedical lens rather than applying a biopsychosocial model. The objectives of this review were to evaluate: (1) the psychosocial characteristics of participants with foot/ankle pain compared to participants without foot/ankle pain; (2) the association between psychosocial factors with pain and function in people with foot/ankle pain; and (3) understand the psychosocial factors associated with the lived experience of foot/ankle pain.
A mixed methods systematic review was conducted according to the PRISMA guidelines and guided by the Joanna Briggs Institute methodology for mixed methods systematic reviews. The databases MEDLINE, Embase, CINAHL, SPORTDiscus, PsychInfo, and Scopus were searched. The Mixed Methods Assessment Tool was used to evaluate study quality. A convergent segregated approach was used to synthesise and integrate quantitative and qualitative data.
Eighteen studies were included, consisting of 13 quantitative, 4 qualitative and 1 mixed methods study. The overall quality of the studies was considered high. Integration of the quantitative and qualitative data were not possible due to the disparate nature of the included studies. A narrative synthesis of the quantitative data revealed that negative emotional and cognitive factors were more common in people with foot/ankle pain compared to those without foot/ankle pain. A significant association was also found between emotional distress with foot pain and foot function in some people with plantar heel pain. In addition, kinesiophobia and pain catastrophising were significantly associated with impaired foot function, and pain catastrophising was significantly associated with first step pain in people with plantar heel pain. The qualitative data revealed emotional impacts, physical challenges, and a loss of self which was individual and unpredictable.
This review provides evidence that negative psychological constructs are greater in participants with foot/ankle pain compared to those without foot/ankle pain, although the cross-sectional nature of the study designs included in this review reduces the certainty of the evidence. These findings indicate that psychological constructs are associated with foot/ankle pain. Further research should evaluate the predictive ability of multidimensional screening tools to identify patients at risk of developing persistent foot/ankle pain.
Foot and ankle (foot/ankle) pain is common in the community. Foot pain is estimated to have a prevalence between 13 and 36%  and ankle pain has an approximate prevalence of 12% . Compared to other body regions, the foot/ankle is the third most common site of self-reported joint pain for adults aged over 55 years . The presence of foot/ankle pain is a risk factor for functional impairments such as locomotor disability , impaired balance , and increased risk of falls . In addition to functional impairments, the presence of foot/ankle pain is a risk factor for reduced health-related quality of life .
Factors associated with the presence of foot/ankle pain should be viewed through a biopsychosocial model, which describes foot/ankle pain as a result of the interaction between biological, psychological and social factors . This model shifts the focus from the pathophysiological processes associated with nociception and reinforces the influence of a person’s emotional state, cognitive processes, and subsequent behaviour on pain . Interestingly, there is no evidence for any musculoskeletal condition that a direct relationship exists between tissue pathology and/or a radiographic finding, and a person’s experience of pain, including its intensity .
Emotional factors such as depression, anxiety and general indicators of emotional distress are more common in people with persistent pain than in pain-free controls for a range of conditions (e.g., mixed, back, head, neck, fibromyalgia, arthritis) . Cognitive factors, which relate to how individuals think about their pain, have also been found to be associated with the experience of pain. For example, pain catastrophising is associated with increased pain intensity, pain-related disability, and psychological distress - even when controlling for level of physical impairment . The perception of pain may also be associated with coping behaviours that produce positive outcomes, or behaviours that are maladaptive such as avoidance behaviours, which might be associated with further dysfunction, depression and pain .
An awareness of psychological factors is important for health professionals to broadly understand an individual’s experience of pain. If negative psychological factors are found to be more common, or more severe, in individuals with foot/ankle pain or associated with their pain or function, health professionals can assess and address these factors. A recent systematic review evaluated the association between psychological factors and clinical outcomes in tendinopathy, with studies related to plantar heel pain (n = 3) and Achilles tendinopathy (n = 1) being among the included studies. The review concluded a weak to moderate strength of association between psychological factors and pain, disability and physical functional outcome in tendinopathy from 10 observational studies. Longitudinal data failed to show a predictive relationship between baseline psychological factors and long-term outcomes . Although these findings are of interest, the review needs to be considered in light of some limitations. For example, the review did not include other musculoskeletal conditions of the foot/ankle (e.g., osteoarthritis) or qualitative research related to the lived experience of people with foot/ankle pain. The synthesis and integration of qualitative data applied to research questions can add value by providing more insightful ways to understand the nature of an individual’s experience, and in this case the biopsychosocial aspects of foot/ankle pain.
Therefore, the aim of this mixed methods review is to synthesise quantitative and qualitative data to investigate psychosocial factors in people with foot/ankle pain. This will be achieved by (i) determining the psychosocial characteristics of participants with foot/ankle pain compared to participants without foot/ankle pain, (ii) determining psychosocial factors that are associated with pain and function in people with foot/ankle pain, and (iii) identifying psychosocial factors associated with a participant’s lived experience of foot/ankle pain.
The protocol was registered with PROSPERO (CRD42020200764) and no deviations to the protocol were made after registration. The review is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines  and guided by the Joanna Briggs Institute (JBI) methodology for mixed methods systematic reviews .
Adult participants with foot/ankle pain of at least 1 month duration were included. We excluded studies in which participants experienced pain associated with surgery, fractures, infections, tumours, systemic inflammatory disorders, neurological disorders, and participants that had concurrent pain in regions outside the foot/ankle.
The quantitative component of this review considered studies that evaluated the likelihood of having foot/ankle pain in the presence of a psychological factor(s) and also studies that evaluated the association between psychological factors with foot pain and foot function.
Phenomena of interest
Qualitative studies that investigated the lived experience of people with foot/ankle pain were considered for analysis.
The quantitative component of this review considered studies which reported at least one self-reported outcome that evaluated a psychological variable.
The qualitative component of the review included studies that investigated the lived experience of community dwelling people with foot/ankle pain.
Types of studies
This review considered quantitative, qualitative and mixed methods studies. Quantitative studies included randomised controlled trials, cohort, cross-sectional and case-control designs. Qualitative studies included data relevant to the proposed phenomena of foot/ankle pain. Methodologies of interest included qualitative design, phenomenology, ethnography, grounded theory, action research and the qualitative component of mixed methods studies. Mixed methods studies were only included if the data from the quantitative and qualitative components of the study could be extracted and synthesised. Narrative reviews, editorials, conference abstracts, non-published studies (e.g., theses), single case studies, and non-primary literature (e.g., systematic reviews) were excluded.
The search strategy was developed and refined through discussion with the authors and a librarian. The search strategy, including all identified keywords and index terms were adapted for each included database. In March 2021, the following electronic databases were searched: MEDLINE, Embase, CINAHL, SPORTDiscus, PsychInfo, and Scopus. A full electronic search strategy from the CINAHL database is included in Supplementary file 1. The reference lists of all included articles were hand searched for studies meeting the inclusion criteria.
Following the search, all identified citations were collated and uploaded into EndNote X9 (Clarivate Analytics, PA, USA) and duplicates were removed. Relevant titles and abstracts were independently screened by pairs of reviewers (MC and NF) with disagreements resolved by a third team member (DRB or GAW). Full-text articles were retrieved and assessed against the inclusion criteria by two independent reviewers (MC and NF). Full-text studies that did not meet the inclusion criteria were excluded, and reasons for exclusion were provided. Disagreements that arose between the reviewers were resolved through discussion with a third reviewer (DRB or GAW).
Assessment of methodological quality
Two reviewers (DRB and GAW) independently assessed the methodological quality of the included studies using the Mixed Methods Appraisal Tool (MMAT) . The MMAT is a reliable  and valid  quality assessment tool designed to facilitate critical appraisal of studies included in systematic mixed studies reviews (i.e., reviews that include qualitative, quantitative, and mixed methods studies) . All included studies were initially assessed against two screening questions relating to the research question/s and the studies’ data to ensure they were empirical studies. Following this, the quality of each study was appraised by rating the criteria in the relevant category based on the study design. All methodological quality criteria were documented as ‘yes’, ‘no’ or ‘can’t tell’, with the latter recorded when insufficient information was available to provide a ‘yes’ or ‘no’ response. Reviewers met and discussed any discrepancies until all ratings were agreed.
For quantitative studies, four reviewers (MC, DRB, GAW and NF) extracted data including specific details about the study design and setting, and participant characteristics such as age, gender, BMI, level of education, degree of pain, level of function, psychosocial outcome measure and outcomes of significance to the review question. The lead author (MC) checked all extracted data for accuracy.
For the qualitative component, two reviewers (MC and NF) independently extracted study information using the JBI QARI Data Extraction Tool for Qualitative Research  and disagreements were resolved through discussion. Through repeated reading of the included studies, extracted findings were identified as a verbatim extract of a theme or metaphor that was developed through the authors’ data analysis. Each finding that was extracted was accompanied by an illustration that informed the finding and included a direct quotation of a participant’s voice. The two independent reviewers then allocated a level of credibility to each extracted finding, as follows:
Unequivocal – findings with illustrations that are beyond reasonable doubt and thus not open to challenge.
Credible – findings with an illustration that are not closely associated with the finding and is open to challenge.
Unsupported – findings not supported by the data.
If more than one illustration was provided for a finding, the illustration with the highest level of credibility was allocated to the finding. Unsupported findings, where there was no quotation of the participant voice, were excluded from further analysis and synthesis.
A narrative synthesis of quantitative data was used to evaluate psychological characteristics in people with foot/ankle pain compared to people without foot/ankle pain and also to investigate the association between psychological factors and measures of pain and function. Statistical pooling was not possible.
Meta-aggregation  was used to synthesise qualitative data to understand the lived experience of participants with foot/ankle pain including the psychosocial factors associated with their experience. To complete this synthesis, unequivocal or credible findings were independently grouped into categories by MC and NF (Supplementary file 2) based on similarity of meaning, ensuring that there were at least two or more like findings per category. The categories were then reviewed by the same authors to develop consensus. An explanatory statement was then developed by MC and NF that conveyed the inclusive meaning of a group of similar findings. The categories were then evaluated by the same authors, and those with commonality were aggregated into synthesised findings. As with categories, an explanatory statement was also developed, which represented conclusions based on the findings from the included studies that conveyed the inclusive meaning of a group of similar categories. All synthesised findings were reviewed by each author.
Integration of the quantitative and qualitative data were limited because the data were not complimentary. As a result, a narrative synthesis was conducted, which involved comparing the results from the quantitative synthesis with the qualitative synthesis and analysing the association between psychosocial factors with foot/ankle pain while considering the experiences of the participants.
A total of 6585 studies were identified through electronic databases (Fig. 1). After removal of duplicates, 5285 titles were screened. 5216 studies were subsequently excluded leaving 69 studies to be assessed for full-text retrieval and MMAT analysis. Following the quality analysis, 18 studies met the eligibility criteria and were available for analysis. Reasons for excluding 51 studies can be found in Supplementary File 3.
In total, the review included 6906 participants. Of the 18 studies included, seven were cross-sectional studies with comparative data from an asymptomatic control group [21,22,23,24,25,26,27]; five were cross-sectional studies without comparative data [28,29,30,31,32]; one was a cohort study ; four were qualitative studies [34,35,36,37]; and one was a mixed methods study . Of the qualitative and mixed method studies, three related to Achilles tendinopathy [35, 36, 38], one to plantar heel pain  and one to osteoarthritis of the ankle .
The specific details of the MMAT quality ratings for each of the 18 studies are provided in Table 1. Of the 14 studies that included quantitative data, a ‘yes’ was awarded for the majority of the five methodological quality criteria for this category. However, 13 of the 14 quantitative studies were allocated a ‘no’ for the criterion Are the confounders accounted for in the design and analysis? (criterion 3.4), as they did not report the presence or absence of pain elsewhere in the body, which could have confounded the study’s reported outcome measures (i.e., psychological variables).
The overall methodological quality of the four qualitative studies was high, with all studies receiving a ‘yes’ for all five methodological quality criteria for this category, indicating appropriate methodology and reporting of findings.
Regarding the only mixed methods study , a ‘yes’ was allocated for all qualitative and quantitative items, except for criterion 3.4. For the five criteria relating specifically to mixed methods studies (criteria 5.1 to 5.5.), a ‘no’ was provided for the criteria Are the outputs of the integration of qualitative and quantitative components adequately interpreted? (criterion 5.3) and Are divergences and inconsistencies between quantitative and qualitative results adequately addressed? (criterion 5.4), while all other criteria were allocated a ‘yes’.
The characteristics of the participants included in the quantitative studies and qualitative studies are described in Table 2 and Table 3, respectively. The quantitative studies had a mean sample size of 411 (range 27 to 3321), while the qualitative studies had a mean sample size of 12. The only mixed methods study in the review included 92 participants that completed an online survey and 11 participants that participated in a focus group. Forty nine percent of participants, across all studies, were female.
Below is a narrative synthesis of studies that evaluated the psychological characteristics of participants with foot/ankle pain compared to participants who were an asymptomatic control (n = 7), and studies that investigated the association between psychological factors and foot/ankle pain and/or foot function (n = 5) (Table 4).
Psychological characteristics of people with foot/ankle pain compared to participants without foot/ankle pain
Symptoms of depression were compared with asymptomatic controls in five studies [21,22,23, 25, 27]. In a sample of 3321 participants, after adjusting for age and BMI, men had a 1.84 increased odds (95% CI 1.4 to 2.5) and women a 1.93 increased odds (95% CI 1.5 to 2.4) of reporting symptoms of depression compared to those without foot pain . Results from a cohort of 796 community dwelling males found that foot pain was significantly associated with self-reported depression (OR 2.16 [95% CI 1.4 to 3.3]) . Shivarathre et al.  also found that symptoms of depression were significantly higher in participants with foot and/or ankle pain. In studies that provided a specific diagnosis to explain the origin of symptoms, Cotchett et al. , found that participants with a diagnosis of plantar heel pain (PHP) had greater levels of depression, compared to controls (mean difference = 4.4, 95% CI 2.3 to 6.5), while Chimenti et al.  found no difference in self-reported symptoms of depression in a group with and without Achilles tendinopathy.
Two studies evaluated symptoms of anxiety in participants with and without pain. Shivararthre et al.  found that anxiety was significantly higher in a group of participants with foot/ankle pain, while Cotchett et al.  found that symptoms of anxiety were significantly higher in participants with PHP compared to a group without PHP (mean difference = 2.6, 95% CI 0.9 to 4.3). In the same study, analysis of a stress subscale of the DASS-21 found that symptoms of stress were significantly higher in the group with PHP compared to those without PHP (mean difference = 4.8, 95% CI 1.9 to 7.8).
Three studies evaluated kinesiophobia. Palomo-Lopez et al.  found that kinesiophobia was higher in participants with Stage II, Stage III and Stage IV hallux valgus compared to an asymptomatic group without hallux valgus, although the difference was only significant for the comparison between Stage IV hallux valgus and the asymptomatic comparator. In people with Achilles tendinopathy, there were contrasting findings from two studies. One study found no differences in kinesiophobia scores between participants with and without symptoms associated with Achilles tendinopathy , while another found significantly higher levels of kinesiophobia in a group with Achilles tendinopathy compared to a group without symptoms .
One study evaluated catastrophising in participants with and without pain. Chimenti et al.  found significantly higher pain catastrophising scores in a group with Achilles tendinopathy (mean 12.6, 95% CI 9.2 to 15.9) compared to a control group (mean 1.9, 95% CI −1.5 to 5.2).
Other psychological factors
In a survey of 636 nurses working in a teaching hospital in Japan, there was an increased odds of high job strain (OR 1.57, 95% CI 1.05 to 2.30) and low job control (OR 1.42, 95% CI 1.02 to 2.00) compared to those without foot/ankle pain.
The association between psychological factors with foot pain and foot function
Two studies found a significant association between depression and stress with pain in people with PHP, although Cotchett et al.  found that the association between depression and pain (β = − 0.41; p = 0.013) and stress and pain (β = − 0.36; p = 0.024) were significant in females and not males. In contrast, Harutaichun et al.  found anxiety was strongly associated with pain in Thai male conscripts with PHP (β = 0.41, P = 0.01), while stress (β = − 0.50; p = 0.001) and depression (β = − 0.53; p < 0.001) were also associated with foot function in females with PHP, but not males .
Cotchett et al.  found that kinesiophobia (β = − 1.60; p = 0.006) and pain catastrophising (β = − 1.61; p < 0.001) were significantly associated with foot function, while pain catastrophising (β = − 0.93; p = 0.008) was significantly associated with first step pain in people with PHP. Similarly, kinesiophobia was significantly associated with lower extremity function in participants with general foot/ankle pain (β = 0.40, p = 0.001) .
From one mixed methods and four qualitative studies, three synthesised findings were identified from eight categories and 52 findings. Of the five studies, three evaluated the lived experience of participants with Achilles tendinopathy , one focused on PHP  while another investigated participants with osteoarthritis of the ankle . Of the three synthesised findings, two related to psychological factors associated with the participant’s lived experience (synthesised finding 1.0 and 3.0). Synthesised finding 4.0 was unrelated to psychological factors but rather focused on living with foot/ankle pain and the perceptions of the management process by health professionals. Table 5 provides a summary of the findings, illustrations, categories and synthesised findings from one mixed methods and four qualitative studies.
Synthesised finding 1.0. Participants report variability and uncertainty about factors associated with the development of Achilles tendinopathy, PHP and osteoarthritis of the ankle. Fear avoidance behaviours appear common and might be associated with the belief that exercise may worsen pain and cause further injury or tendon rupture
This synthesised finding was derived from two categories, one of which related to psychological factors associated with the participants’ experience of Achilles tendinopathy and ankle osteoarthritis.
Category 1.2. Activity beliefs
Participants reported having significantly modified or ceased their activity because of a fear of further injury, damage and/or an increase in pain:
“I often just pull out earlier then. I never let it get that bad, if you know what I mean? I don’t really go in as hard. I’ve got that kind of doubt niggling in the back of my mind about it. That I need to protect it, rather than let it get too bad. So I’m not someone who would take it that far to the edge. I think that’s probably more of it, it just hinders me from going further or harder, or any of those things really” (participant with Achilles tendinopathy) .
“There is the fear of it reoccurring ... the fear of triggering an attack prevents you from doing stuff” (participant with Achilles tendinopathy) .
“I can get away with doing it, it’s afterwards, when I stop, it doesn’t, it’s endless... but wow the pain I felt over the following days. It’s like we’d go to the park and I don’t want to risk it. I don’t want to risk it and then it affect me; not moving tomorrow” (participant with osteoarthritis of the ankle)” .
Synthesised finding 3.0. The impact of Achilles tendinopathy, PHP and osteoarthritis of the ankle is individual, presenting with emotional, physical challenges and a loss of self
The synthesised finding was derived from three categories, two of which related to psychological factors.
Category 3.2. Pain impacts on emotions
Some participants with Achilles tendinopathy noted the negative impact on their mental health including feeling depressed, stressed and a sense of hopelessness:
“I don’t want to overstate the cranky and anger stuff, but there’s definitely a general feeling of—it’s almost depression, but not clinical depression, but you just don’t feel good about yourself or the world” (participant with Achilles tendinopathy) .
“I’m a mouse on a wheel. I can’t seem to get off. I don’t know what to do. I don’t know how to lose weight without moving, and how do you move without the pain? So yeah, sometimes I’m a bit exasperated by it” (participant with PHP) .
“I got quite depressed with it all. I didn’t realise that there was such an adverse effect that the pain grinds you down and gives you that low self-esteem and no self-confidence. You can see other people your age doing things but you’re not able to. It wears you down mentally and makes you very depressed at times. What you don’t realise is it’s not just physical, it very much affects you mentally” (participant with osteoarthritis of the ankle) .
In addition, participants described frustration and/or annoyance with their condition and management:
“Well, I think it’s just like there’s things that I enjoy doing and if I can’t do them, now I get a bit frustrated and it’s part of what makes me happy and makes me satisfied with things” (participant with Achilles tendinopathy) .
“But honestly, if someone told me to mix up a special drink cause that’s what was gonna fix it that’s probably what I’d do as well. So, I probably am trying anything. It’s a bit like spin the wheel and try your luck. I’ll try it all” (participant with plantar heel pain) .
Category 3.3. Loss of self
Participants with Achilles tendinopathy and osteoarthritis of the ankle described a negative impact on self-image and self-esteem:
“I’d also say that, in some respects, it (running) defines who I am, and so, if I can’t do that, it’s taking who I am away from me. That’s tough... Well the self-esteem certainly goes down, because you’re not who you were” (participant with Achilles tendinopathy) .
“Seeing my peers going to races, winning races or getting PBs. Progressing ... and I’m stuck here. That has been horrendous I have to say. Now, I know there are worse things in life that can happen. But it’s been horrible” (participant with Achilles tendinopathy) .
“I’m just useless, just because of a daft ankle. It’s unbelievable that isn’t it. It makes me feel as if I’m good for nothing, I might as well just turn it in, you know, just go for a couple of tablets and I’ll call it a day. Just a waste of time. I’m good for nothing at the minute. I feel like crying. It’s horrible. Every day of my life; it gets a bit upsetting. You just wanna give in, in the end, you get sick of it” (participant with osteoarthritis of the ankle) .
“… I didn’t realise that there was such an adverse effect that the pain grinds you down and gives you that low self-esteem and no self-confidence …”(participant with osteoarthritis of the ankle) .
Integration of quantitative evidence and qualitative evidence
Integration of the quantitative and qualitative data were not possible due to the disparate nature of the evidence available. More specifically, the majority of the qualitative data related to the lived experience of participants with Achilles tendinopathy, which might not directly relate to other musculoskeletal conditions explored in the quantitative review such as PHP, hallux valgus, ankle sprains and general foot pain. As such, a narrative synthesis was undertaken.
Despite the disparate evidence, the results from individual syntheses were mostly supportive. The quantitative data, which highlighted that the emotional [21,22,23, 25] and cognitive  state of participants with foot/ankle pain was different to people without foot and/or ankle pain, might be explained by elements of the qualitative data. Most participants with Achilles tendinopathy, PHP and osteoarthritis of the ankle described frustration associated with their experience of pain and the inability to undertake activities that brought enjoyment, often leading to a loss of self, a loss of social connections and an inability to manage emotions due to pain and functional limitations. For some participants, frustration may be associated with emotional distress due to feelings of despair, helplessness, pain-related fear and unfulfilled needs, which might be due to the uncertainty of the diagnosis, management, and prognosis of the condition. Some participants were clearly frustrated and dissatisfied with the treatment process offered by health professionals, including the uncertainty of professional opinion and the type and level of education received.
There were some aspects of the quantitative evidence that were not directly explored in the qualitative studies. For example, pain catastrophising was significantly higher in people with foot/ankle pain compared to those without foot/ankle pain and was associated with increased pain severity and poor function in people with PHP, however the domains relating to magnification, rumination and helplessness were not explored in the qualitative studies. In addition, the quantitative evidence found that symptoms of depression were associated with the presence of foot/ankle pain, although the qualitative evidence did not provide a deep or rich exploration of these symptoms in people with Achilles tendinopathy or PHP. However, a few participants with osteoarthritis of the ankle described a substantial impact of their condition on their emotional state. There were also several aspects of the qualitative data that were not explored in the quantitative studies. For example, a loss of self was evident in the studies by McAuliffe et al.  and Turner et al.  although this was not a variable that was evaluated in the quantitative studies.
The purpose of this mixed methods systematic review was to evaluate and understand the psychological characteristics of people with foot/ankle pain. A comprehensive search of the evidence found 18 studies that met the inclusion criteria using quantitative, qualitative and mixed methods designs. A range of conditions were explored including non-specific foot pain, PHP, Achilles tendinopathy, painful hallux valgus and osteoarthritis of the ankle. The overall methodological quality of the studies was rated as high, although the quantitative findings were largely derived from observational cross-sectional studies, which reduces the certainty of the evidence. The review identified negative psychological characteristics of participants with foot/ankle pain that differed from participants without pain, and an association between negative psychological factors with foot pain and foot function for certain conditions. In addition, qualitative findings revealed that the experience of pain has a negative impact on emotions and function, is associated with pain-related fear, but also a loss of self. Due to the disparate nature of the evidence available, integration of the quantitative and qualitative data were not possible.
Psychological factors in participants with and without foot/ankle pain
Four of seven cross-sectional studies reported increased symptoms of depression and anxiety in participants with foot/ankle pain compared to those without. This finding is consistent with other musculoskeletal conditions such as patellofemoral pain , knee arthroplasty  and back pain . However, despite the perceived association between symptoms of emotional distress and foot/ankle pain, the results have largely been derived from cross sectional studies that had limited statistical control over confounding factors that might be associated with the outcome. In addition, the clinical relevance of the difference in psychological features between people with and without foot/ankle pain is uncertain due to the wide range of psychological measures that were used to evaluate emotional distress, preventing data from being pooled.
Psychological factors associated with foot pain and foot function
Two studies found a significant association between emotional distress with foot pain and foot function in people with PHP, although regression analyses found contrasting findings. Cotchett et al.  found a significant association between depression and pain and stress and pain in females (but not males), while anxiety was not associated with pain in males or females with PHP. In contrast, Harutaichun et al.  found (using the same outcome measure) a significant association between anxiety and pain among male Thai conscripts. The contrasting findings may be explained by differences between the samples. The male Thai participants were younger and had a substantially higher anxiety level compared to participants in the Cotchett et al.  study, which might be related to performance demands and the continuing physical threat associated with being a Thai conscript in the military .
Cotchett et al.  also found that kinesiophobia and pain catastrophising were significantly associated with foot function, and pain catastrophising was significantly associated with first step pain in people with PHP. Similarly, kinesiophobia was significantly associated with lower extremity function in participants with general foot/ankle pain. These findings are consistent with other research that found kinesiophobia has a moderate positive relationship with disability , and pain catastrophising is associated with pain in other musculoskeletal conditions [44,45,46].
The lived experience of people with foot/ankle pain
The four qualitative and one mixed methods study provided rich data about cognitive factors associated with foot/ankle pain but also the emotional impact and a loss of self. Descriptions of fear avoidance behaviours were common and might stem from the belief that exercise may worsen pain and cause further injury or tendon rupture. However, the impact of Achilles tendinopathy, PHP and osteoarthritis of the ankle was individual with some participants presenting with emotional distress, physical challenges, and a loss of self. These findings are consistent with other musculoskeletal conditions such as knee osteoarthritis , patellofemoral pain , low back , and shoulder pain , and highlights the importance of listening to and understanding the patient’s perspectives and context related to their experience of pain.
Gender disparities related to psychological factors and pain
In studies that reported data from females and males separately, symptoms of depression were higher in females compared to males  , which is consistent with the prevalence of depression amongst females and males in the wider community .
In studies where the severity of foot pain was stratified by gender, females reported higher levels of general foot/ankle pain  and also PHP compared to male counterparts . This disparity is also consistent with the experience of pain for females and males in the community. Research has indicated that females with osteoarthritis of the knee experience more widespread pain, increase frequency of daily pain, and increased pain related to affective symptoms compared to males .
Strengths and limitations
There are several strengths of this review which include pre-registration with PROSPERO, reporting according to the PRISMA guidelines and adhering to the JBI approach to Mixed Methods Systematic Reviews. However, this review should be considered in light of some limitations. The review is limited by the small number of studies that evaluated participants over time, so it is not possible to evaluate the temporal relationships between psychological factors and foot/ankle pain. In addition, cross-sectional studies are subject to selection bias introduced by the study investigator or the participant themselves . Confounding might be an issue for many of the cross-sectional studies as other factors known to be associated with pain or function were not attended to, which might reduce the validity of the true association between the psychological variable and the outcome of interest .
Recommendations for practice
Due to the cross-sectional nature of most of the included studies, caution is required when making recommendations for practice. However, there is growing evidence that psychological factors are associated with the experience of pain including the development and maintenance of persistent musculoskeletal pain, and therefore should be assessed in people with foot/ankle pain .
The psychological factors reported in this review are not routinely assessed by many health professionals who treat musculoskeletal pain. This may be due to inadequate training and/or the inability to apply theory to practice . There is clearly a need for better screening of psychological risk factors to identify patients who may be at risk of poor clinical outcomes. Screening can first occur during the patient interview to understand the patient’s context but also their perspective of their experience of pain and disability. The interview provides the framework for screening of psychological factors by using a multidimensional screening tool (e.g., Orebro Musculoskeletal Pain Screening Questionnaire)  to identify people at a high risk of a poor outcome due to psychological factors. If appropriate, a unidimensional measure can then be used to specifically identify psychological factors to enhance clinical reasoning and implement a psychologically informed treatment.
Recommendations for research
There is clearly enough evidence from cross-sectional studies to support an association between psychological factors and foot/ankle pain. However, the direction of the relationship needs to be determined through longitudinal studies to explore the temporal relationship between pain and psychological factors. In addition, there is a need for more mixed methods studies so that quantitative data can be used to explain findings from qualitative data, but also the qualitative inquiry can help develop hypotheses for testing in the quantitative component. Future studies could consider exploring in more depth the source and impact of frustration in people with foot/ankle pain, which might be amenable to treatment by health professionals through acknowledgement, reassurance, and better communication. Future research should determine the predictive ability of multidimensional screening tools in identifying patients at risk of developing persistent foot/ankle pain. Finally, a large number of studies were excluded during the screening process as a specific psychological factor was not evaluated. Rather, many studies evaluated health related quality of life. While such generic measures are important to evaluate multiple components such as an individual’s physical health, mental, and social relationships future research should consider supplementing these measures with disease-specific measures to address clinically important positive and negative changes in psychological factors.
This review provides evidence that negative psychological constructs are higher in participants with foot/ankle pain compared to those without foot/ankle pain, and an association between negative psychological factors with foot pain and foot function for certain conditions. In addition, the experience of pain has a negative impact on emotions and function, is associated with pain-related fear and a loss of self. However, the cross-sectional nature of the study designs included in this review reduce the certainty of the evidence. The review highlights the importance of assessing foot-related musculoskeletal pain through a biopsychosocial model lens.
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Additional file 1:.
Supplementary file 1 – Medline database search strategy (03/03/2021).
Additional file 2:.
JBI QARI Data Extraction Tool for Qualitative Research_Ceravolo (Data extracted by Frescos).
Additional file 3:.
Supplementary file 2 – List of excluded studies.
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Cotchett, M., Frescos, N., Whittaker, G.A. et al. Psychological factors associated with foot and ankle pain: a mixed methods systematic review. J Foot Ankle Res 15, 10 (2022). https://doi.org/10.1186/s13047-021-00506-3
- Mental health
- Musculoskeletal pain
- Plantar fasciitis
- Achilles tendon