This article has Open Peer Review reports available.
Investigation of the biomechanical effect of variable stiffness shoe on external knee adduction moment in various dynamic exercises
© Teoh et al.; licensee BioMed Central Ltd. 2013
Received: 13 December 2012
Accepted: 22 August 2013
Published: 17 September 2013
The growing ageing population and high prevalence of knee osteoarthritis (OA) in athletes across nations have created a strong demand for improved non-invasive therapeutic alternatives for knee OA. The aim of this study is to investigate the effect of the variable stiffness shoe (VSS), a new non-invasive therapeutic approach, on external knee adduction moment (EKAM) in various dynamic exercises. EKAM is believed to have positive correlation with the progression and development of knee OA.
Thirty young participants (16 male and 14 female; age 22.6 ± 1.9 years) from National University of Singapore were enrolled in this study. The tested activities were walking, running, drop-landing, and lateral hopping. All the dynamic exercises were recorded simultaneously by the 8-camera VICON Motion Systems (Oxford Metric, UK) with a sampling rate of 100 Hz.
The results showed that the EKAM was reduced in all the dynamic exercises with the use of VSS. The VSS produced significant reductions in the peak EKAM during walking (4.97%, p = 0.039), running (11.15%, p = 0.011), drop-landing (11.18%, p = 0.038) and lateral hopping (17.34%, p = 0.023) as compared to the control shoe.
The reduction of EKAM with the use of VSS in various dynamic exercises demonstrates its potential in delaying the onset and the progression of knee OA in early stage of knee OA patients.
KeywordsKnee osteoarthritis (OA) Variable stiffness shoe (VSS) External knee adduction moment (EKAM)
Osteoarthritis (OA) is the most prevalent joint disorder in the world , resulting from the biochemical breakdown of articular cartilage in the synovial joints. At present, 33.6% of the U.S. population aged above 65 are affected by this condition . Research also shows that athletes are more prone to the early onset of knee OA with 3.3% prevalence of OA in elite athletes compared to 1.4% in non athletes  due to periodic mechanical impact on knee during sports activities [4–7]. Vigorous sports such as football, rugby, and hockey are found to expose the players to higher risk of developing OA [7, 8].
Out of the many joints in the human body, knee OA is the most common type of osteoarthritis . 25% of knee OA population have difficulty in walking 1/4 mile and climbing the stairs while 15% have to use assistive device such as a cane for walking . The profound impact of knee OA on quality of life and the serious implication of total joint replacement have led to great research interest in designing new preventive approaches.
The majority of knee OA is diagnosed in the medial condyle of the knee . During walking, the forces passing through the medial compartment can be 2.5 times greater than that through the lateral compartment [11, 12]. Tetsworth and Paley  postulated a 4-6% increase in varus alignment will further increase the medial loading across the knee joint by 20%. Malalignment of the knee, by altering the load distribution, can hence be deemed as a risk factor of knee OA .
The external knee adduction moment (EKAM) is the product of ground reaction force (GRF) and the moment arm with respect to knee joint center. It has been demonstrated to be a valid indicator for medial compartment loading [14–17]. An increase in EKAM causes adduction at the tibiofemoral joint and eventually elevates compressive load at the medial compartment of the knee joint. This rise of joint forces is undesirable as it results in a negative deleterious effect on knee cartilage and contributes to development and progression of OA [12, 18–24].
It was reported in the study by Sharma et al.  that the widely used OA pathogenesis could be categorized into two, i.e. (1) Increased regional load across the articulating joint and (2) altered material properties of articular cartilage which affect its ability to withstand compressive load. Due to the strong association of EKAM and medial loading, as well as the causative link between medial loading and development of knee OA, many believe that greater EKAM values indicated higher risk in knee OA [12, 25–28]. In line with this, EKAM can be a predictor of knee OA development . Hence, it is important to study how EKAM changes under different therapeutic approaches in order to examine their effects in reducing risk of developing knee OA.
On the other hand, Vanwanseele et al.  demonstrated that no associations were found between the severity of OA and the EKAM although significantly higher EKAM and knee adduction angular impulse were observed in the subgroup of medial OA patients. Furthermore, a case-study using instrumented knee prosthesis showed that a reduction in first peak EKAM does not guarantee a reduction in medial contact load  and Bennell et al.  also showed that medial knee load was not affected by EKAM. Therefore, changes in EKAM may not accurately reflect changes in knee OA progression. Direct measurements of changes in medial contact force seems to be a more appropriate way to determine the effectiveness of therapeutic approaches on knee OA progression, nonetheless, the in vivo knee contact forces cannot be easily measured. Hence, EKAM is still a good predictor of medial knee OA progression  to examine the effect of VSS. Erhart et al.  indicated that EKAM peak was significantly correlated with decreases of medial peak force in a participant with a total knee replacement.
A summary of the biomechanical effect of interventions presented in the literature
Reductions in 1stPeak of EKAM
High Tibial Osteotomy (surgical intervention)
Bhatnagar et. al 
30 HTO patients
58% (No significant difference between 6 and 12 months post-HTO)
Birmingham et. al 
126 patients with knee OA
Weidenhielm et. al 
9 patients after high tibial valgus osteotomy
Laterally Wedged Insoles (Footwear intervention)
Shimada et. al 
23 patients with medial knee OA
Kerrigan et. al 
15 patients with clinical and radiographic OA
6% (in 5° wedge)
8% (in 10° wedge)
Crenshaw et. al 
15 normal healthy subjects
Variable Stiffness Shoe (Footwear intervention)
Jenkyn et. al 
32 subjects with medial compartment knee OA
Erhart et. al 
1 subject with total knee replacement
Some participants have voiced their discomfort after using the laterally-wedged insoles . Alternatively, the variable stiffness shoe (VSS), with a stiffer lateral midsole, can potentially be a better approach to reduce EKAM without causing additional discomfort on shoe wearers. Current research has shown the efficacy of VSS in reducing the EKAM and decreasing the knee pain of patients wearing VSS during walking [31, 35, 40, 41]. However, the biomechanical effects of VSS in other dynamic exercises such as running, drop-landing and lateral hopping has yet to be investigated. In fact, it has been reported that men aged between 20–49 who ran more than 20 miles per week had 2.5 times higher risk in developing OA, as compared to sedentary men . Studies showed that long term vigorous activities increase the incidence of OA [42–50]. Nonetheless, there are also reports that indicated no significant increase in risk of OA from physical exercises [51–58]. The relationship between physical activities and OA development is unclear.
Despite the contrary, repetitive movement in exercise is still thought to have potentially adverse effect on knee cartilage due to increased joint forces. Hence it is necessary to investigate the effect of VSS in reducing EKAM during various dynamic exercises. In addition, given the fact that several reports have demonstrated higher knee OA risk in athletes [4–7], biomechanical effects of VSS in dynamic exercises are not well established. It was hypothesized that the EKAM would be lowered during locomotion with the use of VSS.
Participants (n = 30)
16 M / 14 F
Mean age (SD)
22.6 (1.9) years
Body weight (SD)
57.2 (7.9) kg
Body Mass Index (SD)
20.68 (2.23) kg/m2
Gait analysis protocol
All the dynamic exercises were recorded simultaneously by the 8-camera VICON Motion Systems (Oxford Metric, UK). Two side-by-side force plates (AMTI, Massachusetts, US) embedded in a 12m walkway were used to record the magnitude and direction of the ground reaction force (GRF) present during the motion. Both kinematics and kinetics data were sampled at a sampling rate of 100 Hz. A total of sixteen markers were placed on the lower extremities of each participant. Two markers were affixed to each shoe at the second metatarsal head and heel region respectively. Other markers were placed on the ankle, tibia, knee, thigh, anterior superior iliac spine and posterior superior iliac spine. All the markers attached on the skin remained on the participant throughout the entire session in order to minimize the variations in angles and external moments caused by different anatomical reference frame. The kinetic data such as knee joint moments and GRF were retrieved and processed using spreadsheet software.
Walking: Participants were instructed to walk at their natural walking speeds with each foot striking one of the force plates respectively.
Running: Participants were tasked to run at their self-selected speeds with their left foot achieving contact with the force plate.
Drop-landing (Figure 2A, 2B): Participants were asked to perform the drop-landing task at a height of 30cm, beginning from a standing position on a platform. They were subsequently instructed to step off the platform (leading with their dominant leg) and land with each foot on each force plate simultaneously.
Lateral hopping (Figure 2C): Participants were tasked to carry out 3–5 lateral hops before striking the center of the force plate positioned 1.5 m away from the starting point.
All the data collection was preceded by adequate familiarization. Trials were omitted if participants were found to have obvious gait adjustments secondary to visual targeting of the force plates. Three successful trials from each participant were recorded for data analysis.
In addition, the 7-point perception scale questionnaire was also conducted to evaluate the comfort level of the VSS. Three aspects of shoes were rated, i.e. overall comfort, cushioning and stability. Participants were asked to grade the shoes after each activity, 1 being extremely dissatisfied and 7 being extremely satisfied.
All kinetic and kinematic data were averaged for each participant across three trials. GRF data were normalized to body weight (%BW) and the EKAM was normalized to body weight and height (%BW x height) to eliminate intergroup difference. Maximum GRF and EKAM values at the characteristic peaks during each dynamic exercise were obtained from the average curves. The average curves were graphed against the percentage stance in the walking case and graphed against time in other three exercises.
Paired t-tests were used to identify significant differences between the control shoe and the VSS for each dynamic activity. Percentage differences were normalized by the control shoe. Statistical significance was considered as p < 0.05.
Group-mean (standard deviation) values of GRF during running
Variable name (%BW)
Max Medial GRF
Max Vertical GRF
Group-mean (standard deviation) values of EKAM in two different shoe conditions
Variable name (%BW*ht)
EKAM (1st peak)
EKAM (2nd peak)
The objective of this study was to investigate the changes in EKAM with the use of VSS during various dynamic exercises. In spite of the rising incidence of knee OA among athletes worldwide, only the reduction in EKAM throughout stance during walking has been well documented in both healthy participants and participants with different stages of knee OA. To our knowledge this is the first study to report on the reduction in EKAM during other dynamic activities such as running, drop-landing and lateral hopping.
The 5% reduction in peak EKAM during walking in this study is consistent with, or slightly smaller than, that of participants with medial knee OA (KL grades 1–2) studied by Jenkyn et al., of 6.6%  and Erhart et al., of 7% . However, Erhart et al.  found reductions in EKAM, ranging from 13% at the 1st peak to 22% at the 2nd peak, during walking with the VSS. The significantly greater reduction in EKAM observed in that study may be due to either the use of a single participant with a total knee replacement or the gait adaptations undergone by the patient with the implanted knee. Furthermore, this significant reduction in the peak EKAM contradicts the findings of a recent published study by Erhart et al.  in which no significant difference in peak EKAM was found between control and intervention group with severe medial knee OA (KL grades 3–4). An explanation for these differences may be the BMI and age of participants, the walking speed, or the severity of medial knee OA. It is also possible that the VSS is less likely to affect joint moments with a greater varus knee alignment which is usually found in patients with severe knee OA. This explanation, together with the findings reported by Erhart et al. , is consistent with that from a study conducted with the lateral-wedged insole whereby no significant reduction in EKAM was also observed in the participants with severe knee OA during walking . Moreover, the significant reduction in the peak EKAM is in line with the findings reported by Bennell et al. . However, EKAM was also found to be significantly higher in variable stiffness shoe condition as compared to barefoot walking. Since walking barefooted may be impractical under certain circumstances, VSS that resulted in a decrease in EKAM as compared to normal shoe can still be an optimal footwear option for knee OA patients .
The double hump pattern exhibited by the EKAM during walking was not exhibited by the EKAM during running. Instead, there was only a single peak found in the graph of EKAM during running. This may due to the participants who are forefoot strike runners, resulting in the absence of impact peak in the GRF as compared to the typical rear foot strike runners.
The peak EKAM was also significantly reduced in other dynamic exercises (11.18% in drop-landing and 17.34% in lateral hopping). Whilst no direct numerical comparison could be made because this is the first study to report these data, other investigators of VSS have proposed mechanisms that can potentially explain the reduction in peak EKAM during these activities. Boyer et al. reported that the greater ankle eversion angle, the less pelvic obliquity and that hip adduction angle results in lower EKAM during walking by changing the posture of the leg in frontal plane . Such a mechanism is likely to be present during the period of landing and lateral hopping when participants attempt to achieve stability.
The potential mechanism responsible for the decrease in EKAM observed with VSS during walking was presented by Jenkyn et al. . They proposed that the reduction in EKAM is due to the reduction in medial GRF, lateral movement of COM due to dynamic adaptation to the differential stiffness from lateral to medial midsole and the reduction in lever arm caused by the eversion moment of the foot that induces a valgus thrust at the knee. We speculated that the same mechanism is applied on other dynamic exercises apart from walking. It is because the stiffer lateral midsole of the VSS will cause eversion at the ankle joint which eventually leads to the reduction in lever arm. However, the exact mechanism by which the EKAM is reduced was not conclusively demonstrated and future study is needed to find out the exact mechanism.
Furthermore, the VSS also caused an increase in anterior GRF by 12.21% during running. This observation suggests that the participants altered their running gait with the use of VSS such that forward acceleration is enhanced. Such an alteration in running gait is crucial for improving the performance of athletes. Despite the promising results obtained, this study needs to be viewed in light of a few limitations. The main limitation is that participants had a limited adaption period to familiarize themselves with the usage of the VSS before test. This limitation could compromise the accuracy of the findings due to the indirect gait pattern changes caused by unfamiliar footwear. However, it has been demonstrated by Erhart et al. that the reduction in the external knee adduction moment due to the VSS is immediate and sustained for at least a period of 1 year while wearing the shoe . Furthermore, only young healthy participants were involved in the study, the results presented may not be representative of elderly population who are more prone to knee OA . However, recruitment of senior participants may impose another limitation to the study, e.g. gait instability, which may reduce the result accuracy. Another source of error may come from the assessment technique applied. Motion capture using plug in gait model was preferred despite of the several potential errors associated, such as anatomical marker misplacement and soft tissue artifact. To reduce these undesirable errors, marker placements were done by the same trained personnel. At least 5 trials were conducted on each activity to examine experiment repeatability. The best 3 trials were then averaged for comparison purpose.
Acknowledging the limitations of this study, there remains a vast potential in the use of VSS as a means of treatment for early stages of knee OA. Future studies could be directed at a larger participant pool to achieve power to draw conclusions on the differences in EKAM between the intervention and control groups as well as the long-term efficacy of VSS in athletes and osteoarthritic participants. In addition, people with medial knee OA have been reported to have a more pronated foot type compared to normal people . Thus, the VSS may have different effects on this population. Apart from the EKAM, future efforts can also be considered to study other variables in this custom-made shoe design such as stress distribution at hip and ankle joint, plantar soft tissue stiffness after prolonged usage of this intervention  as well as the vertical and shear forces acting on the foot  which are important factors contributing to foot ulceration.
The findings support the hypothesis that the VSS reduces EKAM during dynamic exercises. Furthermore, the results also demonstrate that the change in EKAM may due to the reduction in medial GRF. As the reduction in EKAM may help to delay the onset and the progression of knee osteoarthritis, it can thus be speculated that the VSS might have the potential to serve as a therapeutic intervention for early stage of medial compartment knee OA, thereby delaying the need for invasive surgery.
Interestingly, the VSS also caused an increase in anterior GRF during running. This effect is beneficial to the forward propulsion of athletes and can potentially enhance the performance in various sport activities. However, the exact mechanism behind this remains unknown and further investigation is required to evaluate the effect of VSS in sports performance.
Written informed consent was obtained from the patient for the publication of this report and any accompanying images.
This work was supported by a grant from the Temasek Defence Systems Institute (Project number: TDSI/09-009/1A), Singapore. The authors would also like to thank HwaSeung Corp. Ltd., Korea, for providing the intervention shoes used in this study.
- Arden N, Nevitt MC: Osteoarthritis: Epidemiology. Best Pract Res Cl Rh. 2006, 20: 3-25.View ArticleGoogle Scholar
- Lawrence RC, Felson DT, Helmick CG, Arnold LM, Choi H, Deyo RA, Gabriel S, Hirsch R, Hochberg MC, Hunder GG, et al: Estimates of the prevalence of arthritis and other rheumatic conditions in the United States. Part II. Arthritis Rheum. 2008, 58: 26-35. 10.1002/art.23176.View ArticlePubMedPubMed CentralGoogle Scholar
- Kujala UM, Kaprio J, Sarna S: Osteoarthritis of weight bearing joints of low limbs in former elite male athletes. Br Med J. 1994, 308: 231-234. 10.1136/bmj.308.6923.231.View ArticleGoogle Scholar
- Michaëlsson K, Byberg L, Ahlbom A, Melhus H, Farahmand BY: Risk of severe knee and hip osteoarthritis in relation to level of physical exercise: A prospective cohort study of long-distance skiers in sweden. PLoS ONE. 2011, 6: e18339-10.1371/journal.pone.0018339.View ArticlePubMedPubMed CentralGoogle Scholar
- Lindberg H, Roos H, Gardsell P: Prevalence of coxarthrosis in former soccer players - 286 players compared with macted controls. Acta Orthop Scand. 1993, 64: 165-167. 10.3109/17453679308994561.View ArticlePubMedGoogle Scholar
- Drawer S, Fuller CW: Propensity for osteoarthritis and lower limb joint pain in retired professional soccer players. Br J Sports Med. 2001, 35: 402-408. 10.1136/bjsm.35.6.402.View ArticlePubMedPubMed CentralGoogle Scholar
- Buckwalter JA, Lane NE: Athletics and osteoarthritis. Am J Sports Med. 1997, 25: 873-881. 10.1177/036354659702500624.View ArticlePubMedGoogle Scholar
- Kujala UM, Kettunen J, Paananen H, Aalto T, Battié MC, Impivaara O, Videman T, Sarna AS: Knee osteoarthritis in former runners, soccer players, weight lifters, and shooters. Arthritis Rheum. 1995, 38: 539-546. 10.1002/art.1780380413.View ArticlePubMedGoogle Scholar
- Michaud CM, McKenna MT, Begg S, Tomijima N, Majmudar M, Bulzacchelli MT, Ebrahim S, Ezzati M, Salomon JA, Kreiser JG, et al: The burden of disease and injury in the United States 1996. Population Health Metrics. 2006, 4:Google Scholar
- Mündermann A, Dyrby CO, Hurwitz DE, Sharma L, Andriacchi TP: Potential strategies to reduce medial compartment loading in patients with knee osteoarthritis of varying severity: reduced walking speed. Arthritis Rheum. 2004, 50: 1172-1178. 10.1002/art.20132.View ArticlePubMedGoogle Scholar
- Shelburne KB, Torry MR, Pandy MG: Contributions of muscles, ligaments, and the ground-reaction force to tibiofemoral joint loading during normal gait. J Orthop Res. 2006, 24: 1983-1990. 10.1002/jor.20255.View ArticlePubMedGoogle Scholar
- Baliunas AJ, Hurwitz DE, Ryals AB, Karrar A, Case JP, Block JA, Andriacchi TP: Increased knee joint loads during walking are present in subjects with knee osteoarthritis. Osteoarthritis Cartilage. 2002, 10: 573-579. 10.1053/joca.2002.0797.View ArticlePubMedGoogle Scholar
- Tetsworth K, Paley D: Malalignment and degenerative arthropathy. Orthop Clin N Am. 1994, 25: 367-377.Google Scholar
- Zhao D, Banks SA, Mitchell KH, D'Lima DD, Colwell CW, Fregly BJ: Correlation between the knee adduction torque and medical contact force for a variety of gait patterns. J Orthop Res. 2007, 25: 789-797. 10.1002/jor.20379.View ArticlePubMedGoogle Scholar
- Shelburne KB, Torry MR, Steadman JR, Pandy MG: Effects of foot orthoses and valgus bracing on the knee adduction moment and medial joint load during gait. Clin Biomech. 2008, 23: 814-821. 10.1016/j.clinbiomech.2008.02.005.View ArticleGoogle Scholar
- Schipplein OD, Andriacchi TP: Interaction between active and passive knee stabilizers during level walking. J Orthop Res. 1991, 9: 113-119. 10.1002/jor.1100090114.View ArticlePubMedGoogle Scholar
- Hurwitz DE, Sumner DR, Andriacchi TP, Sugar DA: Dynamic knee loads during gait predict proximal tibial bone distribution. J Biomech. 1998, 31: 423-430. 10.1016/S0021-9290(98)00028-1.View ArticlePubMedGoogle Scholar
- Setton LA, Mow VC, Muller FJ, Pita JC, Howell DS: Altered structure-function relationships for articular cartilage in human osteoarthritis and an experimental canine model. Agents Actions. 1993, 39: 27-48. 10.1007/BF01972710.View ArticlePubMedGoogle Scholar
- Radin EL, Burr DB, Caterson B, Fyhrie D, Brown TD, Boyd RD: Mechanical determinants of osteoarthrosis. Semin Arthritis Rheum. 1991, 21: 12-21.View ArticlePubMedGoogle Scholar
- Frost HM, Jee WSS: Perspectives: Applications of a biomechanical model of the endochondral ossification mechanism. Anat Rec. 1994, 240: 447-455. 10.1002/ar.1092400403.View ArticlePubMedGoogle Scholar
- Hovis KK, Stehling C, Souza RB, Haughom BD, Baum T, Nevitt M, McCulloch C, Lynch JA, Link TM: Physical activity is associated with magnetic resonance imaging-based knee cartilage T2 measurements in asymptomatic subjects with and those without osteoarthritis risk factors. Arthritis Rheum. 2011, 63: 2248-2256. 10.1002/art.30419.View ArticlePubMedPubMed CentralGoogle Scholar
- Imeokparia RL, Barrett JP, Arrieta MI, Leaverton PE, Wilson AA, Hall BJ, Marlowe SM: Physical activity as a risk factor for osteoarthritis of the knee. Ann Epidemiol. 1994, 4: 221-230. 10.1016/1047-2797(94)90100-7.View ArticlePubMedGoogle Scholar
- Yoshimura N, Kinoshita H, Hori N, Nishioka T, Ryujin M, Mantani Y, Miyake M, Takeshita TT, Ichinose M, Yoshiida M, et al: Risk factors for knee osteoarthritis in Japanese men: A case–control study. Mod Rheumatol. 2006, 16: 24-29. 10.1007/s10165-005-0450-6.View ArticlePubMedGoogle Scholar
- Sharma L, Hurwitz DE, Thonar EJMA, Sum JA, Lenz ME, Dunlop DD, Schnitzer TJ, Kirwan-Mellis G, Andriacchi TP: Knee adduction moment, serum hyaluronan level, and disease severity in medial tibiofemoral osteoarthritis. Arthritis Rheum. 1998, 41: 1233-1240. 10.1002/1529-0131(199807)41:7<1233::AID-ART14>3.0.CO;2-L.View ArticlePubMedGoogle Scholar
- Astephen JL, Deluzio KJ: Changes in frontal plane dynamics and the loading response phase of the gait cycle are characteristic of severe knee osteoarthritis application of a multidimensional analysis technique. Clinical Biomechanics. 2005, 20: 209-217. 10.1016/j.clinbiomech.2004.09.007.View ArticlePubMedGoogle Scholar
- Amin S, Luepongsak N, McGibbon CA, LaValley MP, Krebs DE, Felson DT: Knee adduction moment and development of chronic knee pain in elders. Arthritis Care Res. 2004, 51: 371-376. 10.1002/art.20396.View ArticleGoogle Scholar
- Russell EM, Hamill J: Lateral wedges decrease biomechanical risk factors for knee osteoarthritis in obese women. J Biomech. 2011, 44: 2286-2291. 10.1016/j.jbiomech.2011.05.033.View ArticlePubMedGoogle Scholar
- Miyazaki T, Wada M, Kawahara H, Sato M, Baba H, Shimada S: Dynamic load at baseline can predict radiographic disease progression in medial compartment knee osteoarthritis. Ann Rheum Dis. 2002, 61: 617-622. 10.1136/ard.61.7.617.View ArticlePubMedPubMed CentralGoogle Scholar
- Vanwanseele B, Eckstein F, Smith RM, Lange AK, Foroughi N, Baker MK, Shnier R, Fiatarone Singh MA: The relationship between knee adduction moment and cartilage and meniscus morphology in women with osteoarthritis. Osteoarthritis Cartilage. 2010, 18: 894-901. 10.1016/j.joca.2010.04.006.View ArticlePubMedGoogle Scholar
- Bennell KL, Bowles KA, Wang Y, Cicuttini F, Davies-Tuck M, Hinman RS: Higher dynamic medial knee load predicts greater cartilage loss over 12 months in medial knee osteoarthritis. Ann Rheum Dis. 2011, 70: 1770-1774. 10.1136/ard.2010.147082.View ArticlePubMedGoogle Scholar
- Erhart JC, Dyrby CO, D'Lima DD, Colwell CW, Andriacchi TP: Changes in in vivo knee loading with a variable-stiffness intervention shoe correlate with changes in the knee adduction moment. J Orthop Res. 2010, 28: 1548-1553. 10.1002/jor.21183.View ArticlePubMedPubMed CentralGoogle Scholar
- Shimada S, Kobayashi S, Wada M, Uchida K, Sasaki S, Kawahara H, Yayama T, Kitade I, Kamei K, Kubota M, Baba H: Effects of disease severity on response to lateral wedged shoe insole for medial compartment knee osteoarthritis. Arch Phys Med Rehabil. 2006, 87: 1436-1441. 10.1016/j.apmr.2006.08.018.View ArticlePubMedGoogle Scholar
- Kerrigan DC, Lelas JL, Goggins J, Merriman GJ, Kaplan RJ, Felson DT: Effectiveness of a lateral-wedge insole on knee varus torque in patients with knee osteoarthritis. Arch Phys Med Rehabil. 2002, 83: 889-893. 10.1053/apmr.2002.33225.View ArticlePubMedGoogle Scholar
- Crenshaw SJ, Pollo FE, Calton EF: Effects of lateral-wedged insoles on kinetics at the knee. Clin Orthop Relat Res. 2000, 375: 185-192.View ArticlePubMedGoogle Scholar
- Jenkyn TR, Erhart JC, Andriacchi TP: An analysis of the mechanisms for reducing the knee adduction moment during walking using a variable stiffness shoe in subjects with knee osteoarthritis. J Biomech. 2011, 44: 1271-1276. 10.1016/j.jbiomech.2011.02.013.View ArticlePubMedGoogle Scholar
- Bhatnagar T, Jenkyn TR: Internal kinetic changes in the knee due to high tibial osteotomy are well-correlated with change in external adduction moment: An osteoarthritic knee model. J Biomech. 2010, 43: 2261-2266. 10.1016/j.jbiomech.2010.05.001.View ArticlePubMedGoogle Scholar
- Birmingham TB, Giffin JR, Chesworth BM, Bryant DM, Litchfield RB, Willits K, Jenkyn TR, Fowler PJ: Medial opening wedge high tibial osteotomy: A prospective cohort study of gait, radiographic, and patient-reported outcomes. Arthritis Care Res. 2009, 61: 648-657. 10.1002/art.24466.View ArticleGoogle Scholar
- Weidenhielm L, Svensson OK, Brostrom LA, Rudberg U: Change in adduction moment about the knee after high tibial osteotomy and prosthetic replacement in osteoarthrosis of the knee. Clinical Biomechanics. 1992, 7: 91-96. 10.1016/0268-0033(92)90021-U.View ArticlePubMedGoogle Scholar
- Hinman RS, Bennell KL: Advances in insoles and shoes for knee osteoarthritis. Curr Opin Rheumatol. 2009, 21: 164-170. 10.1097/BOR.0b013e32832496c2.View ArticlePubMedGoogle Scholar
- Boyer KA, Federolf P, Lin C, Nigg BM, Andriacchi TP: Kinematic adaptations to a variable stiffness shoe: Mechanisms for reducing joint loading. J Biomech. 2012, 45: 1619-1624. 10.1016/j.jbiomech.2012.04.010.View ArticlePubMedGoogle Scholar
- Erhart-Hledik JC, Elspas B, Giori NJ, Andriacchi TP: Effect of variable-stiffness walking shoes on knee adduction moment, pain, and function in subjects with medial compartment knee osteoarthritis after 1 year. J Orthop Res. 2012, 30: 514-521. 10.1002/jor.21563.View ArticlePubMedGoogle Scholar
- Cheng Y, Macera CA, Davis DR, Ainsworth BE, Troped PJ, Blair SN: Physical activity and self-reported, physician-diagnosed osteoarthritis: Is physical activity a risk factor?. J Clin Epidemiol. 2000, 53: 315-322. 10.1016/S0895-4356(99)00168-7.View ArticlePubMedGoogle Scholar
- Hart DJ, Doyle DV, Spector TD: Incidence and risk factors for radiographic knee osteoarthritis in middle-aged women: The Chingford study. Arthritis Rheum. 1999, 42: 17-24. 10.1002/1529-0131(199901)42:1<17::AID-ANR2>3.0.CO;2-E.View ArticlePubMedGoogle Scholar
- Sutton AJ, Muir KR, Mockett S, Fentem P: A case–control study to investigate the relation between low and moderate levels of physical activity and osteoarthritis of the knee using data collected as part of the Allied Dunbar National Fitness Survey. Ann Rheum Dis. 2001, 60: 756-764. 10.1136/ard.60.8.756.View ArticlePubMedPubMed CentralGoogle Scholar
- Sandmark H, Vingård E: Sports and risk for severe osteoarthrosis of the knee. Scand J Med Sci Spor. 1999, 9: 279-284.View ArticleGoogle Scholar
- Sarna S, Kaprio J, Kujala UM, Koskenvuo M: Health status of former elite athletes. The Finnish experience. Aging Clin Exp Res. 1997, 9: 35-41.View ArticleGoogle Scholar
- McAlindon TE, Wilson PWF, Aliabadi P, Weissman B, Felson DT: Level of physical activity and the risk of radiographic and symptomatic knee osteoarthritis in the elderly: The Framingham study. Am J Med. 1999, 106: 151-157. 10.1016/S0002-9343(98)00413-6.View ArticlePubMedGoogle Scholar
- Lane NE, Hochberg MC, Pressman A, Scott JC, Nevitt MC: Recreational physical activity and the risk of osteoarthritis of the hip in elderly women. J Rheumatol. 1999, 26: 849-854.PubMedGoogle Scholar
- Felson DT, Zhang Y, Hannan MT, Naimark A, Weissman B, Aliabadi P, Levy D: Risk factors for incident radiographic knee osteoarthritis in the elderly. Arthritis Rheum. 1997, 40: 728-733. 10.1002/art.1780400420.View ArticlePubMedGoogle Scholar
- Cooper C, Snow S, McAlindon TE, Kellingray S, Stuart B, Coggon D, Dieppe PA: Risk factors for the incidence and progression of radiographic knee osteoarthritis. Arthritis Rheum. 2000, 43: 995-1000. 10.1002/1529-0131(200005)43:5<995::AID-ANR6>3.0.CO;2-1.View ArticlePubMedGoogle Scholar
- Manninen P, Riihimäki H, Heliövaara M, Suomalainen O: Physical exercise and risk of severe knee osteoarthritis requiring arthroplasty. Rheumatology. 2001, 40: 432-437. 10.1093/rheumatology/40.4.432.View ArticlePubMedGoogle Scholar
- Lau EC, Cooper C, Lam D, Chan VNH, Tsang KK, Sham A: Factors associated with osteoarthritis of the hip and knee in Hong Kong Chinese: Obesity, joint injury, and occupational activities. Am J Epidemiol. 2000, 152: 855-862. 10.1093/aje/152.9.855.View ArticlePubMedGoogle Scholar
- Bagge E, Bjelle A, Eden S, Svanborg A: Factors associated with radiographic osteoarthritis: Results from the population study 70-year-old people in Goteborg. J Rheumatol. 1991, 18: 1218-1222.PubMedGoogle Scholar
- Cooper C, McAlindon T, Snow S, Vines K, Young P, Kirwan J, Dieppe P: Mechanical and constitutional risk factors for symptomatic knee osteoarthritis: Differences between medial tibiofemoral and patellofemoral disease. J Rheumatol. 1994, 21: 307-313.PubMedGoogle Scholar
- White JA, Wright V, Hudson AM: Relationships between habitual physical activity and osteoarthrosis in ageing women. Publ Health. 1993, 107: 459-470. 10.1016/S0033-3506(05)80172-6.View ArticleGoogle Scholar
- Panush RS, Schmidt C, Caldwell JR: Is running associated with degenerative joint disease?. JAMA. 1986, 255: 1151-1154.View ArticleGoogle Scholar
- Lane NE, Oehlert JW, Bloch DA, Fries JF: The relationship of running to osteoarthritis of the knee and hip and bone mineral density of the lumbar spine: A 9 year longitudinal study. J Rheumatol. 1998, 25: 334-341.PubMedGoogle Scholar
- Hannan MT, Felson DT, Anderson JJ, Naimark A: Habitual physical activity is not associated with knee osteoarthritis: The Framingham Study. J Rheumatol. 1993, 20: 704-709.PubMedGoogle Scholar
- Chen WM, Park J, Park SB, Shim VPW, Lee T: Role of gastrocnemius-soleus muscle in forefoot force transmission at heel rise - A 3D finite element analysis. J Biomech. 2012, 45: 1783-1789. 10.1016/j.jbiomech.2012.04.024.View ArticlePubMedGoogle Scholar
- Chen WM, Lee T, Lee PVS, Lee JW, Lee SJ: Effects of internal stress concentrations in plantar soft-tissue-A preliminary three-dimensional finite element analysis. Med Eng Phys. 2010, 32: 324-331. 10.1016/j.medengphy.2010.01.001.View ArticlePubMedGoogle Scholar
- Bennell KL, Kean CO, Wrigley TV, Hinman RS: Effects of a modified shoe on knee load in people with and those without knee osteoarthritis. Arthritis Rheum. 2013, 65: 701-709. 10.1002/art.37788.View ArticlePubMedGoogle Scholar
- Felson DT, Naimark A, Anderson J, Kazis L, Castelli W, Meenan RF: The prevalence of knee osteoarthritis in the elderly. The Framingham Osteoarthritis Study. Arthritis Rheum. 1987, 30: 914-918. 10.1002/art.1780300811.View ArticlePubMedGoogle Scholar
- Levinger P, Menz HB, Fotoohabadi MR, Feller JA, Bartlett JR, Bergman NR: Foot posture in people with medial compartment knee osteoarthritis. J Foot Ankle Res. 2010, 3:Google Scholar
- Chen W-M, Phyau-Wui Shim V, Park S-B, Lee T: An instrumented tissue tester for measuring soft tissue property under the metatarsal heads in relation to metatarsophalangeal joint angle. J Biomech. 2011, 44: 1801-1804. 10.1016/j.jbiomech.2011.03.031.View ArticlePubMedGoogle Scholar
- Chen WM, Vee-Sin Lee P, Park SB, Lee SJ, Phyau Wui Shim V, Lee T: A novel gait platform to measure isolated plantar metatarsal forces during walking. J Biomech. 2010, 43: 2017-2021. 10.1016/j.jbiomech.2010.03.036.View ArticlePubMedGoogle Scholar
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.