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Long-term functional and radiographic outcomes in 243 operated ankle fractures
© Verhage et al. 2015
Received: 4 January 2015
Accepted: 6 August 2015
Published: 25 August 2015
Large comparative studies that have evaluated long-term functional outcome of operatively treated ankle fractures are lacking. This study was performed to analyse the influence of several combinations of malleolar fractures on long-term functional outcome and development of osteoarthritis.
Retrospective cohort-study on operated (1995–2007) malleolar fractures. Results were assessed with use of the AAOS- and AOFAS-questionnaires, VAS-pain score, dorsiflexion restriction (range of motion) and osteoarthritis. Categorisation was determined using the number of malleoli involved.
243 participants with a mean follow-up of 9.6 years were included. Significant differences for all outcomes were found between unimalleolar (isolated fibular) and bimalleolar (a combination of fibular and medial) fractures (AOFAS 97 vs 91, p = 0.035; AAOS 97 vs 90, p = 0.026; dorsiflexion restriction 2.8° vs 6.7°, p = 0.003). Outcomes after fibular fractures with an additional posterior fragment were similar to isolated fibular fractures. However, significant differences were found between unimalleolar and trimalleolar (a combination of lateral, medial and posterior) fractures (AOFAS 97 vs 88, p < 0.001; AAOS 97 vs 90, p = 0.003; VAS-pain 1.1 vs 2.3 p < 0.001; dorsiflexion restriction 2.9° vs 6.9°, p < 0.001). There was no significant difference in isolated fibular fractures with or without additional deltoid ligament injury. In addition, no functional differences were found between bimalleolar and trimalleolar fractures. Surprisingly, poor outcomes were found for isolated medial malleolar fractures. Development of osteoarthritis occurred mainly in trimalleolar fractures with a posterior fragment larger than 5 %.
The results of our study show that long-term functional outcome is strongly associated to medial malleolar fractures, isolated or as part of bi- or trimalleolar fractures. More cases of osteoarthritis are found in trimalleolar fractures.
Ankle fractures are commonly seen at emergency departments, accounting for approximately 10 % of all fractures . In general, stable fractures are treated with cast immobilisation, whereas unstable fractures are mainly treated by internal fixation [2, 3]. In the literature, little attention is given to the long-term functional outcome of operatively treated ankle fractures. Some studies have compared combined uni and bimalleolar fractures to trimalleolar fractures [4, 5]. Whereas other studies have focused on the long-term influence of deltoid ligamentous injury in addition to a fibular fracture, or on the role of the posterior fragment in ankle fractures [6–10]. To our knowledge, no study has compared the long-term results of operatively treated unimalleolar fractures with bimalleolar and trimalleolar fractures. In this study, we analysed the influence of the number and location of malleolar fractures on long-term function, pain, range of motion and development of osteoarthritis in 243 operatively treated participants.
In this retrospective cohort study we included all participants with an ankle fracture, who were operatively treated in our clinic from 1995 until 2007. Exclusion criteria were open fractures, epiphyseal fractures, pathological fractures, pilon fractures, previous ankle fracture on the same side, polytrauma patients, age under 18 years at the time of trauma and older than 75 years at the time of follow-up. No Wet Medisch Onderzoek requirement (Medical Research in Humans) was needed according to the local Medical Ethical Committee. All participants who met the inclusion criteria were invited to participate in the study. If the patient did not have a current phone number or address, the family doctor’s registry was used to obtain the current phone number or address. If patients still could not be reached, the patients were considered lost to follow-up. Patients willing to participate provided written informed consent after being informed about the study.
Radiographic assessment and surgical procedure
Functional outcome was assessed using the American Orthopaedic Foot and Ankle Society (AOFAS) [13, 14], the American Academy of Orthopaedic Surgeons (AAOS)  and the VAS-pain scale. Evaluation of osteoarthritis was performed with a standardised model that grades osteoarthritis into 4 categories; Grade 1: no osteophytes, no joint space narrowing; Grade 2: small osteophytes, no joint space narrowing; Grade 3: moderate osteophytes, joint space narrowing; Grade 4: large osteophytes, severe joint space narrowing .
The collected data were statistically analysed with SPSS, Version 17.0. Major endpoints were function, VAS-pain, dorsiflexion restriction of the affected ankle compared to the contralateral non-fractured side and degree of osteoarthritis. Normally distributed continuous data were compared between groups with parametric tests (t-test or ANOVA). In case of skewed distribution in numerical data, the Mann–Whitney test or the Kruskal-Wallis test was used. For categorical data, the Fisher’s exact test or chi-squared test was used. A two-tailed p-value below 0.05 was considered as statistically significant.
Posterior fragment (%)
Nineteen complications occurred in 19 (7.8 %) participants, mainly in those with trimalleolar fractures. In the total population, mechanical or technical problems (loose screws) occurred in 5 cases, reoperation was necessary in 3 participants (all because of secondary widening of the syndesmosis), and superficial or deep infection occurred in 14 participants (all participants were sufficiently treated by oral antibiotics). Talocrural arthrodesis (2 participants) or ankle-prosthesis (1 participant) was necessary due to severe post-traumatic osteoarthritis. Due to pain or discomfort removal of the implants took place in 70 (29 %) participants after 13 months on average.
Overview of study results
OA grade 1
OA grade 2
OA grade 3
OA grade 4
Fibular fractures with additional posterior fragment had a significantly better functional outcome than trimalleolar fractures (Table 2; AOFAS 97 vs 88, p = 0.040; AAOS 98 vs 90, p = 0.011; VAS 1.0 vs 2.3, p = 0.006; dorsiflexion restriction 3.3° vs 6.9°, p = 0.034). The size of the posterior fragment did not differ significantly between these two groups (respectively 13 and 17 %). No significant differences were found between bimalleolar and trimalleolar fractures on all outcomes (Table 2; AOFAS 91 vs 88, p = 0.180; AAOS 90 vs 90, p = 0.220; VAS-pain 1.8 vs 2.3, p = 0.191; dorsiflexion restriction 6.7° vs 6.9°, p = 0.822). Isolated medial fractures had surprisingly bad results. However, due to the small group size there was no significant difference compared to the other groups.
Results in participants with a posterior malleolar fracture
Size of posterior fragment
OA grade 1
OA grade 2
OA grade 3
OA grade 4
Some degree of osteoarthritis was found in 8 (7 %) unimalleolar fibular fractures, 4 (20 %) fibular fractures with additional posterior malleolar fracture, 4 (9 %) bimalleolar fractures and 22 (37 %) trimalleolar fractures (Table 2). Grade 2 osteoarthritis was present in 20 cases, grade 3 in 14 cases, and grade 4 in only 4 cases (all of whom had trimalleolar fractures). The 3 participants with an ankle-prosthesis or arthrodesis were included in this analysis and all were part of the trimalleolar group. In fractures with involvement of the posterior tibial margin, osteoarthritis was only found in medium-sized (33 %) and large-sized posterior fragments (29 %) (Table 3).
Results in total population classified according the AO-classification
Results in total population classified according the Lauge-Hansen classification
The majority of the participants in this, as far as we know, the largest long-term cohort study of operated ankle fractures showed good results after a mean follow-up of nearly 10 years. In contrast to earlier studies, this study compares large subgroups of operatively treated ankle fractures on long-term outcome where other study groups were small groups or had a short follow-up period.
Previous long-term studies mainly focus on trimalleolar fractures, and especially on the influence of the size of the involved articular surface, and whether or not the posterior fragment should be fixed [7–9]. In other articles, a combined group of uni and bimalleolar fractures are compared to trimalleolar fractures [4, 5]. In 1989, Jaskulka et al. were the first authors to compare the long-term outcome of uni and bimalleolar fractures with trimalleolar fractures . They described a significantly worse outcome in trimalleolar fractures. They also found a worse outcome on function, development of osteoarthritis and pain in trimalleolar fractures with a posterior fragment larger than 5 % compared to posterior fragments smaller than 5 % of the involved articular surface. Limitations of this study are the relatively short follow-up period (5.7 years) and the fact that unimalleolar and bimalleolar fractures were not analysed separately. In a prospective cohort-study with a follow-up period of one year, Tejwani et al. also described a worse outcome of trimalleolar fractures compared to uni and bimalleolar fractures . A small part of that cohort, which was followed for 2 years, showed decreasing differences between the two groups and therefore, the authors concluded that there is no difference between long-term outcome of uni, bi or trimalleolar fractures.
In this study, analysis of isolated fibular fractures was conducted in two subgroups: with or without suspicion of an additional ruptured deltoid ligament (if the medial clear space was >4 mm). There were no significant differences between these subgroups. Therefore, we agree with Donken et al. that additional deltoid ligament injury does not lead to a worse functional outcome in the long-term in operatively treated fibular fractures .
Surprisingly, the outcomes of fibular fractures with an additional posterior fragment were similar to isolated fibular fractures. If bimalleolar fractures are compared with trimalleolar fractures there is no significant difference in functional outcome, except for pain. However, a fracture of the medial malleolus is, according to our data, strongly associated with worse functional outcome.
Despite the large cohort, this study did not show a clear and significant relation between size of the posterior fragment and long-term functional outcome in trimalleolar fractures. Our results suggest that a posterior fragment larger than 5 % leads to a worse outcome compared to posterior fragments smaller than 5 % of the involved articular surface. This is in accordance with Jaskulka et al. . Langenhuijsen et al. described a worse outcome if the posterior fragment is larger than 10 % of the involved articular surface . De Vries et al., Mingo-Robinet et al. and Xu et al. found no clear relationship between posterior fragment size or fixation of the posterior fragment and long-term functional outcome [7, 9, 17].
To clarify these inconsistent findings, we are currently expanding our study with a more recently operated cohort of participants with trimalleolar fractures. Due to the small sample size of the present study, we cannot draw any conclusions with respect to fixation of posterior fragments and the influence on long-term functional outcome as yet.
Unimalleolar and bimalleolar fractures lead to osteoarthritis in only a small percentage of cases. Osteoarthritis in this type of fractures is mainly caused by other factors such as screw displacement or infection. In our series, osteoarthritis occurred mainly in trimalleolar fractures and is therefore thought to be a result of the combination of a posterior malleolar fracture and a medial malleolar fracture. In trimalleolar fractures, the initial cartilage damage in the weight-bearing part of the joint, in combination with the increased peak contact stress and the weight-bearing shift to anterior and medial, with a non-anatomical reduction of the posterior fragment could lead to an increase in development of osteoarthritis [18–22].
A limitation of this study is the 56 % response rate. This study was completed in an inner-city hospital with a poor patient compliance and a highly variable patient population (seasonal workers and several different nationalities). Despite maximum effort to trace these patients many potential participants were lost to follow-up, so there is a risk of selection bias. However, the baseline data and fracture characteristics of the study group were similar to the total group of patients who met the inclusion criteria for the study. This indicates that our study group was representative.
Our data support the assumption that in operated isolated fibular fractures, an additional rupture of the deltoid ligament does not lead to worse outcome. Moreover, the results of our study show that long-term functional outcome is strongly associated to the medial malleolus. Bimalleolar fractures lead to significantly worse functional results than isolated fibular fractures and are comparable to trimalleolar fractures. In case of a posterior fracture, the involvement of the medial malleolus will lead to worse functional outcome, more pain and more development of osteoarthritis.
Source of funding
No funding was necessary to complete this study.
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