Sex differences in the branching position of the nerve to the abductor digiti minimi muscle: an anatomical study of cadavers
© Mizuno et al. 2015
Received: 7 February 2015
Accepted: 6 May 2015
Published: 10 June 2015
The nerve to the abductor digiti minimi muscle (ADMM nerve) is the first branch of the lateral plantar nerve or originates directly from the posterior tibial nerve. Damage to the ADMM nerve is a cause of heel pain and eventually results in ADMM atrophy. It is known that ADMM atrophy occurs more often in females than in males, and the reason remains unclear. This study aimed to explore sex differences in the branching pattern, position, and angle of the ADMM nerve.
Forty-two cadavers (20 males, 22 females) were dissected at Aichi Medical University between 2011 and 2015. Cases of foot deformity or atrophy were excluded and 67 ft (30 male, 37 female) were examined to assess the branching pattern, position, and angle of the ADMM nerve.
The branching positions of the ADMM nerve were superior to the malleolar–calcaneal axis (MCA) in 37 ft (55 %), on the MCA in 10 ft (15 %), and inferior to the MCA in 20 ft (30 %). There was no case among male feet in which the ADMM nerve branched inferior to the MCA, whereas this pattern was observed in 19 of 37 female feet (51 %). The branching position of the ADMM nerve was significantly closer to the MCA in female feet than in male feet. There were no significant sex differences in the branching pattern and angle of the ADMM nerve.
The ADMM nerve sometimes branches off inferior to the MCA in females, but not in males. This difference may be the reason for the more frequent occurrence of ADMM atrophy in females than in males.
KeywordsHeel pain Sex difference Abductor digiti minimi muscle Lateral plantar nerve Posterior tibial nerve Cadaver dissection
There are various causes of heel pain, including plantar fasciitis, plantar fat pad disorders, seronegative spondyloarthropathies, and calcaneal stress fractures. One of the more difficult-to-diagnose causes of heel pain is damage to the nerve to the abductor digiti minimi muscle (hereafter referred to as the ADMM nerve) . It is known that damage to the ADMM nerve eventually results in ADMM atrophy. In a retrospective study, 10 of 476 patients (2.1 %) undergoing magnetic resonance imaging (MRI) of the foot and ankle had ADMM atrophy, suggesting that ADMM atrophy is helpful for confirming the diagnosis of damage to the ADMM nerve . In that study, 9 of the 10 patients (90 %) with ADMM atrophy were females . Furthermore, a prospective study of MRI of ankles and feet demonstrated that 38 of 602 patients (6.3 %) had selective fatty atrophy of the ADMM, with 29 of the 38 patients (76 %) being female . This atrophy was believed to be associated with obesity, presence of a plantar heel spur, and complex and multifocal aberrations in the hindfoot and ankle . However, it remains unclear why ADMM atrophy occurs more often in females than in males.
The nerve bundle innervating the ADMM (i.e., ADMM nerve) has been referred to by several names, including the inferior calcaneal nerve, deep calcaneal nerve, and Baxter’s nerve [4, 5]. The ADMM nerve arises either as the first branch of the lateral plantar nerve or directly from the posterior tibial nerve, and runs in the medial-to-lateral direction between the abductor hallucis muscle and the medial calcaneal tuberosity [6–9]. The ADMM nerve is a mixed sensory and motor nerve that supplies motor branches to the ADMM and, occasionally, supplied the flexor digitorum brevis and quadratus plantae muscles and sensory branches to the calcaneal periosteum and the long plantar ligament . The ADMM nerve runs plantar from its origin, at a significant depth in relation to the abductor halluces muscle. The ADMM nerve changes direction from vertical to horizontal at the inferior margin of the abductor hallucis. As it courses laterally, the nerve lies anterior to the medial process of the calcaneal tuberosity between the quadratus plantae dorsally and the plantar fascia and flexor digitorum brevis muscle in its plantar aspect. The ADMM nerve continues laterally and penetrates the proximal part of the ADMM. A more recent study showed that the ADMM nerve is actually located more posteriorly at an average 5.5 mm anterior to the medial process of the calcaneal tuberosity . However, sex differences in the ADMM nerve are unknown. The aim of this study was to explore sex differences in the branching pattern, position, and angle of the ADMM nerve in cadaveric feet.
Forty-two cadavers (males n = 20, females n = 22) were examined in this study. The cadavers were donated to Aichi Medical University between 2011 and 2015. Before they died, the donors signed documents agreeing to body donation and its use for clinical studies. The format of the document is within the expectation of the Japanese law “Act on Body Donation for Medical and Dental Education.” The average age of the cadavers was 83.2 ± 6.5 years (range, 70–97 years; males, 84 ± 6.4 years; females, 83 ± 7 years). Cases of foot deformity or atrophy were excluded from the analysis, and 67 ft (30 male, 37 female) were dissected to assess the branching pattern, position, and angle of the ADMM nerve. After finding the tibial nerve, the flexor retinaculum was cut to identify the posterior tibial nerve and lateral plantar nerve. The nerves were followed distally to identify the branching positions of the ADMM nerve. The cutaneous branch of the ADMM nerve was also identified.
It is known that the lateral plantar nerve branches off from the posterior tibial nerve under the flexor retinaculum and that the branching position is within 2 cm of the malleolar–calcaneal axis between the top of the medial malleolus and the medial process of the calcaneus . Accordingly, the distance from the branching position of the ADMM nerve to the malleolar–calcaneal axis (A in Fig. 1) was measured with a digital caliper (Sinwa, Model 19979, JPN) and the median value of 3 measurements (in millimeter) was obtained. At the time of measurements, all feet were fixed in the anatomical position after the Achilles tendon was cut, and the plantar aponeurosis and abductor hallusis muscle were removed. The superior side of the malleolar–calcaneal axis was defined as the “plus” direction, and the inferior side was defined as the “minus” direction.
At the piercing point in the ADMM, the angle between the medial process of the calcaneal tuberosity and the branching position of the cutaneous branch of the ADMM nerve (B in Fig. 1) was measured with a digital goniometer (Sinwa, Model SA-5468, JPN) and the median value of 3 measurements was obtained.
All these measurements were performed 3 times in each foot after the ankle joint was fixed in the anatomical position, and the medians were calculated. Sex differences were evaluated using Student’s t-test and the χ2 test. Differences were considered significant if the P value was less than 0.05.
The angle at the piercing point in the ADMM was 107.3 ± 8.3° in males and 106.4 ± 7.1° in females. There was no significant difference in this angle between male and female feet (Fig. 2c, P = .60).
In this study, we assessed sex differences in the branching pattern, position, and angle of the ADMM nerve in cadaveric feet. Because the diameter of the ADMM nerve at the branching position is approximately 2–3 mm, it is difficult to evaluate these differences using MRI or ultrasonography. To the best of our knowledge, this is the first report on sex differences in the branching pattern, position, and angle of the ADMM nerve.
Damage to the ADMM nerve was first reported in 1940 by Roegholt18 and has subsequently been confirmed by numerous authors [1, 4, 8, 11–18]. The damage has been postulated to occur in one of two locations: either at the point where the nerve changes direction at the inferior margin of the abductor halluces, where it is compressed between the abductor hallucis and the medial side of the quadratus plantae, or slightly more distal, where the nerve passes anterior to the medial process of the calcaneal tuberosity [4, 14]. The present study could not find significant sex differences in either the branching pattern or the angle of ADMM nerves in these locations. It has been reported that the scar tissue after plantar fasciitis causes damage to the ADMM nerve ; however, sex differences in the incidence of plantar fasciitis have not been reported. The incidence of a plantar heel spur is higher in females , and Roegholt  reported some cases where a plantar heel spur caused damage to the ADMM nerve. On the other hand, Tanz  argued that the presence of a plantar heel spur is not related to heel pain. Therefore, the extent to which a plantar heel spur affects the prevalence of ADMM nerve damage or ADMM atrophy remains unclear. To determine this relationship, a retrospective study involving MRI data is being planned.
In conclusion, the present study showed that the ADMM nerve branched below the malleolar–calcaneal axis in half of female feet and none of the male feet. Although the reason for the more frequent occurrence of damage to the ADMM nerve in females than in males has not be elucidated sufficiently, this difference may be a cause of the female predominance of nerve damage. Further research is warranted to identify the mechanisms underlying ADMM nerve damage.
The author(s) received no financial support for the research, authorship, and/or publication of this article.
- Baxter DE, Pfeffer GB, Thigpen M. Chronic heel pain. Treatment rationale. Orthop Clin North Am. 1989;20:563–9.PubMedGoogle Scholar
- Stanczak JD, McLean VA, Yao L. Atrophy of the abductor minimi muscle: marker of neuropathic heel pain syndrome. Radiology. 2001;221:522.Google Scholar
- Recht MP, Grooff P, Ilaslan H, Recht HS, Sferra J, Donley BG. Selective atrophy of the abductor digiti quiniti: an MRI study. Am J Roentgenol. 2007;189:123–7.View ArticleGoogle Scholar
- Baxter DE, Thigpen CM. Heel pain: operative results. Foot Ankle. 1984;5:16–25.View ArticlePubMedGoogle Scholar
- Govsa F, Bilge O, Ozer MA. Variations in the origin of the medial and inferior calcaneal nerves. Arch Orthop Trauma Surg. 2006;126:6–14.View ArticlePubMedGoogle Scholar
- Dellon AL, Mackinnon SE. Tibial nerve branching in the tarsal tunnel. Arch Neurol. 1984;41:645–6.View ArticlePubMedGoogle Scholar
- Louisia S, Masquelet AC. The medial and inferior calcaneal nerves: an anatomic study. Surg Radiol Anat. 1999;21:169–73.View ArticlePubMedGoogle Scholar
- Rondhuis JJ, Huson A. The first branch of the lateral plantar nerve and heel pain. Acta Morphol Neerl Scand. 1986;24:269–79.PubMedGoogle Scholar
- Sarrafian SK. Anatomy of the foot and ankle: descriptive, topographic, functional. Philadelphia, PA: Lippincott; 1983.Google Scholar
- Arenson DJ, Cosentino GL, Suran SM. The inferior calcaneal nerve: an anatomic study. J Am Podiatry Assoc. 1990;70:552–60.View ArticleGoogle Scholar
- Baxter DE, Pfeffer GB. Treatment of chronic heel pain by surgical release of the first branch of the lateral plantar nerve. Clin Orthop. 1992;279:229–36.PubMedGoogle Scholar
- Fredericson M, Standage S, Chou L, Matheson G. Lateral plantar nerve entrapment in a competitive gymnast. Clin J Sport Med. 2001;11:111–4.View ArticlePubMedGoogle Scholar
- Henricson AS, Westlin NE. Chronic calcaneal pain in athletes: entrapment of the calcaneal nerve? Am J Sports Med. 1984;12:152–4.View ArticlePubMedGoogle Scholar
- Kenzora JE. The painful heel syndrome: an entrapment neuropathy. Bull Hosp Jt Dis Orthop Inst. 1987;47:178–89.PubMedGoogle Scholar
- Park TA, Del Toro DR. Isolated inferior calcaneal neuropathy. Muscle Nerve. 1996;19:106–8.View ArticlePubMedGoogle Scholar
- Prichasuk S, Subhadrabandhu T. The relationship of pes planus and calcaneal spur to plantar heel pain. Clin Orthop Relat Res. 1994;306:192–6.PubMedGoogle Scholar
- Roegholt MN. Een nervus calcaneus inferior alsoverbrenger, Van de pijn calcaneodynie of calcanensspoor en de daaruit volgende therapie. Ned Tijdschr Geneeskd. 1940;84:1898–902.Google Scholar
- Llanos LF, Vila J, Nunez-Samper M. Clinical symptoms and treatment of the foot and ankle nerve entrapment syndromes. Foot and Ankle Surg. 1999;5:211–8.View ArticleGoogle Scholar
- Przylucki H, Jones CL. Entrapment neuropathy of muscle branch of lateral plantar nerve: a cause of heel pain. J Am Podiatry Assoc. 1981;71:119–24.View ArticlePubMedGoogle Scholar
- Tanz SS. Heel pain. Clin Orthop Relat Res. 1963;28:169–78.PubMedGoogle Scholar
- Nguyen AD, Shultz SJ, Schmitz RJ, Luecht RM, Perrin DH. A preliminary multifactorial approach describing the relationships among lower extremity alignment, hip muscle activation, and lower extremity joint excursion. J Athl Train. 2011;46:246–56.PubMedPubMed CentralGoogle Scholar
- Steinberg N, Finestone A, Noff M, Zeev A, Dar G. Relationship between lower extremity alignment and hallux valgus in women. Foot Ankle Int. 2013;34:824–31.View ArticlePubMedGoogle Scholar
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