Volume 7 Supplement 1

4th Congress of the International Foot and Ankle Biomechanics Community

Open Access

Assessment of tissue glycation on plantar soft tissue stiffness

Journal of Foot and Ankle Research20147(Suppl 1):A83

https://doi.org/10.1186/1757-1146-7-S1-A83

Published: 8 April 2014

Introduction

Tissue glycation, that occurs naturally through ageing and can be sometimes accelerated by disease such as diabetes mellitus, is clinically claimed to have induced irregular collagen alignment and increased collagen fibril density in patients [1]. This hence increases tissue stiffness and leads to plantar injury, i.e. ulcer. In the USA, 85% of all non-traumatic amputations in diabetes patients arise from non-healing ulcers [2]. This tells the need to assess and to detect tissue abnormality early, in order to prevent problematic tissue rupture especially in elderly and diabetes subjects. Currently, there are several existing tools used by clinicians like monofilament, tuning forks, biothesiometers, neurothesiometers etc. However, majority of them only measure subjective sensing ability but not the mechanical property of the plantar tissue. The objective of this study is to investigate the effects of (i) natural tissue glycation (ageing) and (ii) accelerated tissue glycation (diabetes mellitus) on plantar soft tissue stiffness using the proposed indenter [3].

Methods

First experiment investigates the plantar tissue stiffness as a consequence of natural ageing. 25 young (22±1.6 yrs) and 25 old subjects (67±5.8 yrs) of similar physical attributes are recruited. Second experiment involves 35 normal and 5 diabetic subjects of similar physical attributes and ages. It assesses the effect of accelerated tissue glycation due to diabetes on plantar tissue stiffening. During stiffness measurement, indentor tip probes the plantar soft tissue to obtain localized force response underneath the 2nd metatarsal head pad at 3 different dorsiflexion angles of 0°, 20°, 40° and the hallux and heel at 0°. Maximum tissue deformation is fixed at 5.6mm (close to literature data) [4].

Results

Tissue responses are compared (Fig. 1 A&B). Old subjects show significantly higher tissue stiffness in all foot sites tested with p<0.05. Diabetes subjects are found to have stiffer plantar tissue in foot regions tested.
Figure 1

Comparison of plantar STS between (A) young and elderly; (B) diabetic and non diabetic subjects. *p < 0.05

Both natural and accelerated tissue glycation stiffen plantar soft tissue resulting in stiffer and weaker tissue property. This study successfully demonstrates the ability of proposed indentation technique to quantify positive relationship between tissue glycation and plantar soft tissue stiffness.

Authors’ Affiliations

(1)
Department of Biomedical Engineering, National University of Singapore

References

  1. Bai P, et al: Glycation alters collagen fibril organization. Connective Tissue Research. 1992, 28 (1-2): 1-12. 10.3109/03008209209014224.View ArticlePubMedGoogle Scholar
  2. Larsson J: Lower extremity amputation in diabetic patients. 1994, Lund University: Lund UniversityGoogle Scholar
  3. Chen W, et al: An instrumented tissue tester for measuring soft tissue property under the metatarsal heads in relation to metatarsophalangeal joint angle. Journal of Biomechanics. 2011, 44: 1804-1804.View ArticleGoogle Scholar
  4. Cavanagh PR: Plantar soft tissue thickness during ground contact in walking. Journal of Biomechanics. 1999, 32 (6): 623-628. 10.1016/S0021-9290(99)00028-7.View ArticlePubMedGoogle Scholar

Copyright

© Teoh and Lee; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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