Testosterone replacement therapy is associated with increased odds of Achilles tendon injury and subsequent surgery: a matched retrospective analysis

Table 4 Comparison of the likelihood of subsequently undergoing surgery for an Achilles tendon injury

Population and Time Period of Interest	Number of Repairs, n (%)		Regression Analysis
Population and Time Period of Interest	Testosterone Use	Control	aOR^a (95% CI)	p - value
All Patients	287 (9.0)	134 (6.4)	1.54 (1.19 - 1.99)	0.001
Male	231 (9.0)	115 (7.1)	1.24 (0.95 - 1.64)	0.118
35 to 45	67 (10.3)	47 (10.7)	1.00 (0.62 - 1.62)	0.989
46 to 55	71 (8.4)	36 (6.3)	1.23 (0.74 - 2.02)	0.421
56 to 65	68 (9.6)	21 (4.8)	2.07 (1.17 - 3.75)	0.014
66 to 75	25 (7.0)	11 (5.9)	1.08 (0.45 - 2.62)	0.863
Female	56 (8.8)	19 (4.2)	2.57 (1.50 - 4.55)	< 0.001
35 to 45	< 11 (N/A)	< 11 (N/A)	1.89 (0.24 - 17.85)	0.545
46 to 55	21 (8.7)	< 11 (N/A)	2.25 (0.95 - 5.77)	0.074
56 to 65	24 (9.8)	< 11 (N/A)	3.13 (1.33 - 8.25)	0.013
66 to 75	< 11 (N/A)	< 11 (N/A)	2.11 (0.35 - 17.55)	0.432

Bold indicated statistical significance (p < 0.05)
aOR Adjusted odds ratio, CI Confidence interval
^aadjusted used multivariable logistic regression to additionally control for hypogonadism, chronic kidney disease, osteoporosis, overweight/obesity (body mass index > 25), class III obesity (body mass index > 40), alcohol use, osteoarthritis, lung disease, congestive heart failure, and dementia

ISSN: 1757-1146