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Table 3 Comparison of the likelihood of being diagnosed with Achilles tendon injury over a two-year period

From: Testosterone replacement therapy is associated with increased odds of Achilles tendon injury and subsequent surgery: a matched retrospective analysis

Population and Time Period of Interest

Number of Injuries, n (%)

Regression Analysis

Testosterone Use

Control

aORa (95% CI)

p - value

All Patients

3,198 (0.76)

2,081 (0.49)

1.24 (1.15 - 1.33)

< 0.001

Male

2,565 (0.74)

1,630 (0.47)

1.38 (1.29 - 1.49)

< 0.001

 35 to 45

651 (0.81)

441 (0.55)

1.40 (1.21 - 1.61)

< 0.001

 46 to 55

846 (0.82)

567 (0.55)

1.28 (1.13 - 1.46)

< 0.001

 56 to 65

710 (0.76)

435 (0.47)

1.51 (1.31 - 1.74)

< 0.001

 66 to 75

358 (0.53)

187 (0.27)

1.66 (1.35 - 2.03)

< 0.001

Female

633 (0.81)

451 (0.58)

1.44 (1.27 - 1.64)

< 0.001

 35 to 45

74 (0.73)

58 (0.57)

1.29 (0.89 - 1.87)

0.175

 46 to 55

241 (0.85)

185 (0.65)

1.33 (1.08 - 1.64)

0.007

 56 to 65

244 (0.87)

167 (0.59)

1.54 (1.25 - 1.90)

< 0.001

 66 to 75

74 (0.66)

41 (0.36)

1.82 (1.21 - 2.75)

0.004

  1. Bold indicated statistical significance (p < 0.05)
  2. aOR Adjusted odds ratio, CI Confidence interval
  3. aadjusted used multivariable logistic regression to additionally control for hypogonadism, chronic kidney disease, osteoporosis, overweight/obesity (body mass index > 25), class III obesity (body mass index > 40), alcohol use, osteoarthritis, lung disease, congestive heart failure, and dementia