Inclusion Criteria | Exclusion Criteria |
---|---|
Participants who are willing and have capacity to give informed consent. | People who have received a transplant and others receiving immunosuppressant therapy or using long-term oral glucocorticoids other than in the routine management of glucocorticoid deficiency. Participants on a low dose of oral glucocorticoids (<10mgs for ≤7 days) are eligible to participate in the study. |
People with diabetes as diagnosed by the WHO criteria [16] | Participation in another intervention study on active Charcot. |
Age 18 years or over. | Contra-indication for MRI. |
New or suspected diagnosis of acute Charcot (no previous incidence of acute Charcot within the last 6 months on the same foot) treated with off-loading. | Treatment for previous suspected Charcot on the same foot in the last 6 months. |
Understand written and verbal instructions in English. | Suspected or confirmed bilateral active Charcot at presentation. |
Active osteomyelitis at randomisation. | |
Previous contralateral major amputation. | |
Inability to have an MRI scan. | |
People receiving palliative care. |