Table 2 Baseline Characteristics of the included studies
Study ID | Study Arms | Sample | Age, mean (SD) | Gender (N) | BMI, mean (SD) | Glycated Hemoglobin, mean (SD) | Smoking Status (N) | Initial wound area (cm2), mean (SD) | Wound location | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Male | Females | Toe | Forefoot | Midfoot | Heel/ankle/ hindfoot | ||||||||
DiDomenico et al. 2016 | dHACA + SOC | 20 | 59 (13) | 11 | 9 | 37 (9.6) | 7.5 (1.2) | 4 | 2 (0.9) | 4 | 7 | 8 | 1 |
SOC alone | 20 | 58 (9) | 16 | 4 | 37 (11) | 7.8 (1.5) | 2 | 3.3 (4.35) | 4 | 5 | 8 | 3 | |
DiDomenico et al. 2018 | dHACA + SOC | 40 | 60.1 (11.7) | 23 | 17 | 34 (9.3) | 7.6 (1.47) | 4 | 2.1 (1.46) | 10 | 16 | 12 | 2 |
SOC alone | 40 | 61 (10.66) | 31 | 9 | 34.5 (9.42) | 7.9 (1.48) | 3 | 3.1 (3.58) | 3 | 14 | 12 | 5 | |
Lavery et al. 2014 | HVWM (Grafix®) | 50 | 55⋅5 (11.5) | 33 | 17 | 33⋅5 (7.7) | 8 (1.6) | - | 3⋅41 (3.23) | - | - | - | - |
Standard wound care | 47 | 55.1 (12) | 35 | 12 | 32.2 (7.9) | 7.8 (1.5) | - | 3.93 (3.22) | - | - | - | - | |
Zelen et al. 2012 | Standard care | 12 | 56.4 (14.7) | 9 | 4 | 30.4 (5.7) | - | - | 2.6 (1.9) | - | 7 | - | 6 |
EpiFix | 13 | 61·7 (10.3) | 7 | 5 | 35·4 (6.6) | - | - | 3.4 (2.9) | - | 7 | - | 5 | |
Knowlton et al | AMNIOEXCEL (DAMA) | 41 | 57.2 (11.32) | 25 | 16 | - | - | - | - | - | - | - | - |
Standard care | 37 | 59.1 (11.14) | 31 | 6 | - | - | - | - | - | - | - | - | |
Serena et al. 2019 | HSAM + SOC | 38 | 59.2 (7.61) | 30 | 8 | - | - | - | 3.12 (3.86) | - | - | - | - |
SOC alone | 38 | 59.6 (10.72) | 29 | 9 | - | - | - | 3.33 (4.62) | - | - | - | - | |
Snyder et al. 2016 | AMNIOEXCEL (DAMA) + SOC | 15 | 57.9 (12.49) | 12 | 3 | 34.9 (5.9) | - | - | 4.7 (5.43) | 1 | 9 | 3 | 2 |
SOC alone | 14 | 58.6 (6.97) | 13 | 1 | 35.1 (8.1) | - | - | 6.9 (6.75) | 0 | 6 | 5 | 3 | |
Tettelbach et al. 2019 | dHACM | 54 | 57.4 (10.6) | 40 | 14 | 35.8 (8.9) | 7.8 (1.4) | 22 | 3.2 (2.8) | 4 | 27 | 8 | 8 |
SOC alone | 56 | 57.1 (10.5) | 40 | 16 | 34.6 (8.5) | 8.8 (1.8) | 17 | 3.9 (3.8) | 7 | 30 | 8 | 7 | |
Thompson et al. 2019 | Human amniotic allograft + skin substitute + Total contact case | 7 | 58.5 (12.96) | 6 | 1 | - | 9.63 (2.77) | - | 1.54 (1.74) | - | - | - | - |
SOC + Total contact case | 6 | 55.17 (18.32) | 5 | 1 | - | 8.47 (2.44) | - | 2.78 (3.04) | - | - | - | - | |
Zelen et al. 2015 | Epifix | 20 | 63â‹…2 (13) | 10 | 10 | 35 (7.5) | 7.4 (1.5) | 5 | 2.7 (2.4) | 4 | 7 | 2 | 1 |
SOC alone | 20 | 62.2 (12.8) | 9 | 11 | 35.8 (9.7) | 8 (1.5) | 5 | 3.3 (2.7) | 5 | 5 | 3 | 3 | |
Zelen et al. 2016 | Epifix | 32 | 63.3 (12.25) | 19 | 13 | 33.9 (6.9) | 7.5 (1.51) | 9 | 2.6 (2.97) | 9 | 9 | 8 | 6 |
SOC alone | 35 | 60.6 (11.55) | 22 | 13 | 34.7 (9.35) | 8.2 (1.78) | 12 | 3.1 (3.17) | 11 | 12 | 6 | 6 | |