Foot pain and inflammatory markers: a cross sectional study in older adults

Siefkas, Anna C.; Dufour, Alyssa B.; Golightly, Yvonne M.; Menz, Hylton B.; Hillstrom, Howard J.; Hannan, Marian T.

doi:10.1186/s13047-022-00565-0

Journal of Foot and Ankle Research

Table 2 Odds ratios and 95% CI for the association between inflammatory markers (logarithmic scale) and foot outcomes among men and women in the Framingham Foot Study

From: Foot pain and inflammatory markers: a cross sectional study in older adults

	Unadjusted				Adjusted^a
	Men		Women		Men		Women
	OR	P-value	OR	P-value	OR	P-value	OR	P-value
Foot pain
CRP	1.5 (1.1, 2.0)	< 0.01	1.3 (1.0, 1.5)	0.02	1.5 (1.1, 2.0)	0.01	1.1 (0.8, 1.3)	0.67
TNF-α	1.3 (0.6, 2.7)	0.46	1.0 (0.6, 1.6)	0.89	1.5 (0.7, 3.1)	0.31	1.0 (0.6, 1.6)	0.99
IL-6	1.8 (1.2, 2.6)	< 0.01	1.0 (0.7, 1.3)	0.89	1.8 (1.2, 2.6)	< 0.01	0.8 (0.6, 1.1)	0.22
Forefoot pain
CRP	1.9 (1.1, 3.2)	0.03	1.1 (0.9, 1.4)	0.41	1.7 (0.9, 3.1)	0.12	1.0 (0.7, 1.3)	0.75
TNF-α	1.3 (0.3, 6.0)	0.76	0.9 (0.5, 1.8)	0.82	1.6 (0.3, 7.9)	0.55	1.0 (0.5, 1.9)	0.94
IL-6	2.4 (1.2, 4.7)	0.01	1.1 (0.8, 1.7)	0.53	2.9 (1.4, 6.1)	0.01	1.0 (0.7, 1.6)	0.87
Hindfoot pain
CRP	1.2 (0.8, 1.7)	0.48	1.8 (1.2, 2.6)	0.003	1.2 (0.8, 1.9)	0.41	1.4 (0.9, 2.2)	0.13
TNF-α	1.1 (0.4, 3.3)	0.88	0.4 (0.1, 1.0)	0.06	1.3 (0.4, 4.0)	0.65	0.4 (0.1, 1.1)	0.07
IL-6	1.5 (0.9, 2.6)	0.14	1.4 (0.8, 2.3)	0.25	1.7 (1.0, 2.9)	0.07	1.1 (0.6, 1.9)	0.85
Hallux valgus
CRP	0.8 (0.7, 1.0)	0.09	0.9 (0.8, 1.0)	0.16	0.8 (0.6, 1.0)	0.09	0.9 (0.7, 1.1)	0.22
TNF-α	1.1 (0.6, 2.0)	0.83	0.7 (0.5, 1.1)	0.14	1.0 (0.5, 1.9)	0.94	0.6 (0.4, 1.0)	0.06
IL-6	1.1 (0.8, 1.6)	0.45	0.9 (0.7, 1.2)	0.40	1.1 (0.8, 1.6)	0.49	0.9 (0.7, 1.2)	0.33
Hallux rigidus
CRP	1.2 (0.7, 1.9)	0.57	0.9 (0.5, 1.6)	0.77	0.9 (0.5, 1.6)	0.76	1.2 (0.7, 2.3)	0.53
TNF-α	2.1 (0.7, 6.2)	0.19	1.2 (0.3, 5.3)	0.78	2.2 (0.7, 7.0)	0.20	1.3 (0.3, 5.8)	0.71
IL-6	1.0 (0.5, 2.0)	0.99	0.8 (0.3, 2.1)	0.59	0.7 (0.3, 1.7)	0.41	1.0 (0.4, 2.6)	0.94
Toe deformity
CRP	1.0 (0.8, 1.3)	0.88	1.1 (0.9, 1.3)	0.24	0.9 (0.7, 1.2)	0.46	1.1 (0.9, 1.3)	0.50
TNF-α	1.2 (0.7, 2.2)	0.49	1.2 (0.7, 1.8)	0.49	1.0 (0.5, 1.8)	0.94	1.0 (0.6, 1.6)	0.97
IL-6	1.1 (0.8, 1.5)	0.47	1.1 (0.8, 1.5)	0.50	1.0 (0.7, 1.4)	0.80	0.9 (0.7, 1.3)	0.65

Abbreviations: BMI Body mass index, CRP C-reactive protein, IL-6 Interleukin-6, TNF-α Tumor necrosis factor alpha
^a Odds ratios are adjusted for age, body mass index (BMI), smoking status, and physical activity index
Statistically significant associations (p < 0.05) in bold face. Models for TNF-α include a subset of 299 men and 348 women

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