Table 3 Measurement and results of cutaneous microvascular reactivity

Araszkiewicz et al. 2015 [18]

Laser-Doppler (plantar hallux / non-glabrous)

Thermal peak – Median (IQR)

Post-occlusive Reactive Hyperaemia – Median (IQR)

156 (93–240)

142.5 (98–218)

DM: 238 (155–300)

DM: 143 (98–222)

Baker et al. 2007 [23]

Laser-Doppler (dorsal foot / glabrous)

Thermal peak – Mean ± SD

CN: 432 ± 88

CN contralateral foot: 417 ± 110

DPN: 262 ± 71

Healthy: 594 ± 94

Hamdy et al. 2001 [19]

Laser-Doppler (dorsal foot / glabrous)

ACh Iontophoresis – Median (25th – 75th quartiles)

227 (86–554)

DM: 578 (152–1858)

DPN: 90 (15–378)

DPN and PVD: 74 (1-212)

Healthy: 411 (148–641)

Parkhouse et al. 1988 [20]

Laser-Doppler (plantar foot / non-glabrous)

ACh Iontophoresis – Mean

3.0

Type 1 DM: 12.5

DPN + ulcers: 4.7

DM and skin lesions: 5.8

Healthy: 11.5

Shapiro et al. 1998 [24]

Laser-Doppler (dorsal foot / glabrous)

Thermal AuC – Mean ± SD

Thermal vasomotion – Mean ± SD

64.8 ± 56.9

968.2 ± 450.2

DPN: 6.6 ± 1.7

Healthy: 12.9 ± 5.3

DPN: 326.6 ± 176.4

Healthy: 1162.5 ± 279.7

Stevens et al. 1992 [21]*

Laser-Doppler (plantar hallux / non-glabrous)

Thermal peak – Mean ± SD

Acute Charcot 41.0 ± 19.2

CN contralateral foot: 63.4 ± 28.7

DM: 62.7 ± 47

DPN + ulcers: 28.9 ± 37.4

Healthy: 76.3 ± 33.9

Veves et al. 1998 [22]

Microspan TcPO₂ meter (Dorsal foot / glabrous)

Laser-Doppler (dorsal foot)

Thermal peak – Median (IQR)

Post-iontophoresis – Median (IQR)

94 (57–120)

0.3 (0.2–0.4)

DM: 119 (76–175)

DPN: 71 (35–84)

DPN + PVD: 47 (26–64)

Healthy: 127 (99–162)

DM: 0.5 (0.4–0.7)

DPN: 0.3 (0.3–0.4)

DPN + PVD: 0.3 (0.3–0.4)

Healthy: 0.5 (0.3–0.7)