Fig. 1
![Fig. 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs13047-021-00498-0/MediaObjects/13047_2021_498_Fig1_HTML.png)
Participant flow through the study. *COVID-19 loss to follow-up refers to those whose participation in the trial was affected by COVID-19 restrictions
Participant flow through the study. *COVID-19 loss to follow-up refers to those whose participation in the trial was affected by COVID-19 restrictions