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Table 2 Cox regression analysis of variables associated with amputation

From: Rates and risk factors for amputation in people with diabetes in Japan: a historical cohort study using a nationwide claims database

  Univariate analysis P-value Multivariate analysis P-value
HR (95% CI) HR (95% CI)
Age (years) 1.08 (1.02–1.16) 0.01 1.09 (1.02–1.16) 0.01
 Sex 1.40 (0.32–6.17) 0.66  
 BMI 1 kg/m2 increase 0.98 (0.88–1.10) 0.74  
 SBP 10 mmHg increase 1.13 (0.86–1.47) 0.39  
DBP 5 mmHg increase 0.79 (0.63–0.99) 0.04 0.81 (0.64–1.01) 0.07
 LDL-cholesterol 1 mmol/L increase 1.42 (0.85–2.37) 0.18  
 HDL-cholesterol 1 mmol/L increase 0.67 (0.17–2.63) 0.56  
 Current smoking 1.25 (0.46–3.35) 0.66  
HbA1c (%) 1.38 (1.11–1.71) < 0.01 1.46 (1.17–1.81) < 0.01
  1. BMI body mass index, DBP diastolic blood pressure, SBP systolic blood pressure, HR hazard ratio, CI confidence interval, LDL low-density lipoprotein, HDL high-density lipoprotein, HbA1c glycated hemoglobin