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Table 1 Baseline characteristics of study participants according to the presence or absence of lower limb amputation

From: Rates and risk factors for amputation in people with diabetes in Japan: a historical cohort study using a nationwide claims database

Characteristic cardiovascular manifestation in FH Kawaguchi et al. Am Heart J 1999 Lower limb amputation P-value
(−) (+)
n = 17,272 n = 16
Age (years) 50 ± 8 54 ± 10 0.025
≥60 (%) 2137(12) 6 (38) 0.002
Sex (men, %) 14,322 (83) 14 (88) 0.630
BMI (kg/m2) 26.1 ± 4.6 25.7 ± 5.4 0.768
SBP (mmHg) 130 ± 17 134 ± 25 0.556
DBP (mmHg) 80 ± 11 75 ± 14 0.050
HbA1c (%) 7.2 ± 1.4 8.3 ± 2.1 0.054
HbA1c IFCC (mmol/mol) 55 ± 16 67 ± 23 0.054
HbA1c ≥8.0 (%) 3542(21) 8 (50) 0.004
LDL-cholesterol (mmol/L) 3.3 ± 0.9 3.6 ± 1.5 0.449
HDL-cholesterol (mmol/L) 1.4 ± 0.4 1.4 ± 0.4 0.546
Current smoking (%) 6498 (38) 7 (44) 0.613
  1. Data are presented as n (%), mean ± SD. BMI body mass index, HbA1c IFCC glycated hemoglobin, International Federation of Clinical Chemistry and Laboratory Medicine units, SBP systolic blood pressure, DBP diastolic blood pressure, LDL-C low-density lipoprotein-cholesterol, HDL-C high-density lipoprotein-cholesterol