Table 2 Top 10 SNPs from meta-analysis, adjusted for sex, BMI, age, study site, and principal components (total sample, N = 5925)
From: Genome-wide meta-analysis identified novel variant associated with hallux valgus in Caucasians
SNP rsID | Chr:Position | Nearest Gene | EA/OA | EAF | OR (95% CI) | P-value | Direction | I2 | Het. P-value | P-value sens. |
|---|---|---|---|---|---|---|---|---|---|---|
rs55807512 | 1:86916200 | CLCA2 | t/c | 0.96 | 0.48 (0.38, 0.61) | 2.96E-09 | – | 0 | 0.67 | 4.75E-10 |
rs12124247 | 1:86890244 | CLCA2 | a/g | 0.03 | 2.19 (1.68, 2.86) | 7.38E-09 | ++++ | 0 | 0.68 | 2.39E-09 |
rs146496015 | 1:86799387 | ODF2L | t/g | 0.06 | 1.61 (1.34, 1.94) | 3.14E-07 | ++++ | 1.6 | 0.38 | 5.25E-07 |
rs12888772 | 14:81578926 | RP11-114 N19.3 | a/t | 0.18 | 1.30 (1.17, 1.44) | 7.92E-07 | ++++ | 0 | 0.96 | 1.55E-07 |
rs117155606 | 17:54325272 | ANKFN1 | t/c | 0.01 | 5.53 (2.78, 11.02) | 1.13E-06 | ? +??? | 0 | 1 | 1.13E-06 |
rs11728629 | 4:126712045 | RP11-404I7.1 | a/t | 0.24 | 1.26 (1.15, 1.38) | 1.28E-06 | ++++ | 0 | 0.8 | 1.32E-05 |
rs4314298 | 4:126710287 | RP11-404I7.1 | a/g | 0.76 | 0.80 (0.73, 0.87) | 1.42E-06 | – | 0 | 0.82 | 1.52E-05 |
rs116783165 | 5:25669440 | CTD-2533 K21.1 | c/g | 0.03 | 1.72 (1.37, 2.15) | 1.95E-06 | ++++ | 58.6 | 0.06 | 5.56E-06 |
rs116336450 | 5:25663890 | CTD-2533 K21.1 | t/c | 0.97 | 0.58 (0.47, 0.73) | 2.13E-06 | – | 60.5 | 0.06 | 5.87E-06 |
rs79433053 | 5:25668523 | CTD-2533 K21.1 | t/c | 0.03 | 1.71 (1.37, 2.14) | 2.17E-06 | ++++ | 60.3 | 0.06 | 5.98E-06 |