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Table 4 Outcomes changes over time compared to baseline values throughout treatment (marginal estimated mean improvements), by group

From: Should ice application be replaced with neurocryostimulation for the treatment of acute lateral ankle sprains? A randomized clinical trial

 

Mean score change (95% CI)

Time main

effect (RTE)a

(n = 41)

NCS

(experimental

group, n = 20)

Ice

(comparison

group, n = 21)

Functional capacity (LEFS scores, 0–80)

 1 week

22.0 (13.6 to 30.3)

17.6 (10.2 to 25.0)

0.340

 2 weeks

32.8 (26.0 to 39.6)

30.1 (22.4 to 37.7)

0.514

 4 weeks

42.7 (37.2 to 48.1)

38.3 (31.1 to 45.6)

0.716

 6 weeks

45.2 (40.3 to 50.0)

41.6 (33.5 to 49.7)

0.800

Pain at rest (VAS, 0–10)

 1 week

− 0.4 (+ 0.8 to − 1.5)

−1.3 (− 0.6 to − 2.1)

0.375

 2 weeks

−1.1 (+ 0.2 to − 2.3)

−1.9 (− 0.8 to −3.0)

0.534

 4 weeks

− 1.6 (− 0.3 to − 2.9)

− 2.1 (− 0.8 to − 3.4)

0.668

 6 weeks

− 1.8 (− 0.6 to − 2.9)

− 2.2 (− 0.9 to − 3.4)

0.705

Pain during usual activities (VAS, 0–10)

 1 week

− 2.1 (− 0.6 to − 3.6)

− 2.3 (− 1.3 to − 3.3)

0.382

 2 weeks

−2.8 (− 1.5 to − 4.2)

−3.4 (− 2.4 to − 4.4)

0.490

 4 weeks

−3.8 (− 2.4 to − 5.2)

−4.1 (− 2.9 to − 5.3)

0.682

 6 weeks

−4.1 (− 2.7 to − 5.6)

−4.4 (− 3.2 to − 5.6)

0.774

Oedema (Figure-of-8, cm)

 1 week

−0.69 (− 0.05 to − 1.34)

−0.64 (+ 0.11 to − 1.38)

0.496

 2 weeks

− 1.06 (− 0.29 to − 1.83)

−0.56 (+ 0.28 to − 1.40)

0.508

 4 weeks

− 1.24 (− 0.29 to − 2.18)

−0.93 (− 0.19 to − 1.67)

0.532

 6 weeks

−1.15 (− 0.20 to − 2.09)

−0.76 (− 0.05 to − 1.47)

0.519

Dorsiflexion ROM (WBLT, cm)

 1 week

2.4 (− 0.1 to 4.9)

3.6 (1.1 to 6.0)

0.414

 2 weeks

4.1 (1.9 to 6.3)

4.8 (2.2 to 7.4)

0.550

 4 weeks

5.2 (3.0 to 7.4)

5.9 (3.2 to 8.6)

0.643

 6 weeks

5.7 (3.4 to 8.0)

5.9 (3.1 to 8.7)

0.668

  1. aRelative treatment effect (nparLD analysis), for appreciation of the time main effect. Corresponds to an effect size of the time. Values range [0, 1], relative to the null hypothesis (H0) expected value (0,5)
  2. LEFS Lower Extremity Functional Scale, NCS neurocryostimulation, ROM range of motion, RTE relative treatment effect, VAS visual analog scale, WBLT Weight-Bearing Lunge Test.