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Table 2 Univariate predictors of amputation

From: Predictors of lower extremity amputation in patients with diabetic foot ulcer: findings from MEDFUN, a multi-center observational study

Variable

Amputation

P value

OR

95% C.I

Yes

n (%)

No

n (%)

Age ≥ 65 years

29 (37.2)

49 (62.8)

0.874

1.065

0.488–2.325

Gender (male)

67 (36.2)

118 (63.8)

0.734

1.081

0.689–1.695

Diabetes type (type 1)

1 (7.7)

12 (92.3)

0.065

0.145

0.019–1.127

Diabetes duration > 10 years

35 (40.7)

51 (59.3)

0.236

1.356

0.819–2.245

Ulcer duration > 1 month

111 (46.8)

126 (53.2)

<  0.001

10.021

4.656–21.567

Neuropathy

93 (35.5)

169 (64.5)

0.954

1.016

0.592–1.744

PAD

87 (49.4)

89 (50.6)

<  0.001

3.910

2.402–6.365

Ulcer grade (≥ 4)

94 (52.8)

84 (47.2)

<  0.001

5.953

3.544–10.002

Wound infection

99 (38.4)

159 (61.6)

0.041

1.806

1.024–3.183

Proteinuria

54 (44.6)

67 (55.4)

0.021

1.724

1.084–2.741

HbA1c < 7%

3 (17.6)

14 (82.4)

0.097

0.278

0.062–1.259

WBC > 10,000/μL)

78 (44.3)

98 (55,7)

0.001

2.412

1.413–4.118

ESR > 20 (mm/hour)

100 (38.9)

157 (61.1)

0.171

2.454

0.678–8.877

Osteomyelitis

59 (64.8)

32 (35.2)

<  0.001

5.879

3.462–9.983

Anemia

71 (39.4)

109 (60.6)

0.098

1.466

0.932–2.305

Renal impairment

29 (43.9)

37 (56.1)

0.100

1.585

0.916–2.743

  1. PAD peripheral artery disease, HbA1c glycated hemoglobin, WBC white blood cells, ESR erythrocyte sedimentation rate. Note: P value entries in boldface denote statistical significance