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Table 2 Univariate predictors of amputation

From: Predictors of lower extremity amputation in patients with diabetic foot ulcer: findings from MEDFUN, a multi-center observational study

Variable Amputation P value OR 95% C.I
Yes n (%) No n (%)
Age ≥ 65 years 29 (37.2) 49 (62.8) 0.874 1.065 0.488–2.325
Gender (male) 67 (36.2) 118 (63.8) 0.734 1.081 0.689–1.695
Diabetes type (type 1) 1 (7.7) 12 (92.3) 0.065 0.145 0.019–1.127
Diabetes duration > 10 years 35 (40.7) 51 (59.3) 0.236 1.356 0.819–2.245
Ulcer duration > 1 month 111 (46.8) 126 (53.2) <  0.001 10.021 4.656–21.567
Neuropathy 93 (35.5) 169 (64.5) 0.954 1.016 0.592–1.744
PAD 87 (49.4) 89 (50.6) <  0.001 3.910 2.402–6.365
Ulcer grade (≥ 4) 94 (52.8) 84 (47.2) <  0.001 5.953 3.544–10.002
Wound infection 99 (38.4) 159 (61.6) 0.041 1.806 1.024–3.183
Proteinuria 54 (44.6) 67 (55.4) 0.021 1.724 1.084–2.741
HbA1c < 7% 3 (17.6) 14 (82.4) 0.097 0.278 0.062–1.259
WBC > 10,000/μL) 78 (44.3) 98 (55,7) 0.001 2.412 1.413–4.118
ESR > 20 (mm/hour) 100 (38.9) 157 (61.1) 0.171 2.454 0.678–8.877
Osteomyelitis 59 (64.8) 32 (35.2) <  0.001 5.879 3.462–9.983
Anemia 71 (39.4) 109 (60.6) 0.098 1.466 0.932–2.305
Renal impairment 29 (43.9) 37 (56.1) 0.100 1.585 0.916–2.743
  1. PAD peripheral artery disease, HbA1c glycated hemoglobin, WBC white blood cells, ESR erythrocyte sedimentation rate. Note: P value entries in boldface denote statistical significance