Table 1 Demographic, clinical and laboratory characteristics of subjects who underwent lower extremity amputation and those who did not
Variable | Total (n = 336) | Amputation | P value | |
|---|---|---|---|---|
Yes | No | |||
Age (years) | 55.9 ± 12.5 | 56.8 ± 11.3 | 55.6 ± 13.1 | 0.391 |
Gender (male) | 185 (55.1) | 67 (36.2) | 118 (63.8) | 0.734 |
Diabetes type (type 1) | 13 (3.9) | 1 (7.7) | 12 (92.3) | 0.033 |
Diabetes duration (years) | 8.5 ± 5.7 | 9.1 ± 5.7 | 8.1 ± 5.7 | 0.130 |
Ulcer duration (days) | 45.2 ± 41.0 | 63.9 ± 57.8 | 35.0 ± 22.1 | <  0.001 |
Ulcer duration (> 1 month) | 237 (70.5) | 111 (46.8) | 126 (53.2) | <  0.001 |
Neuropathy | 262 (78.0) | 93 (35.5) | 169 (64.5) | 0.954 |
PAD | 176 (52.4) | 87 (49.4) | 89 (50.6) | <  0.001 |
Wagner grades | ||||
 Grade 1 | 13 (3.9) | 0 (0.0) | 13 (100.0) |  |
 Grade 2 | 57 (17.0) | 3 (5.3) | 54 (94.7) |  |
 Grade 3 | 88 (26.2) | 22 (25.0) | 66 (75.0) | <  0.001 |
 Grade 4 | 124 (36.9) | 58 (46.8) | 66 (53.2) |  |
 Grade 5 | 54 (16.1) | 36 (66.7) | 18 (33.3) |  |
Presence of gangrene | 178 (53.0) | 94 (52.8) | 84 (47.2) | <  0.001 |
Wound infection | 258 (76.8) | 99 (38.4) | 159 (61.6) | 0.039 |
Proteinuria | 96 (28.6) | 54 (44.6) | 67 (55.4) | 0.021 |
HbA1c (%) | 9.6 ± 1.9 | 9..9 ± 1.8 | 9.4 ± 2.0 | 0.061 |
White cell count (cells/ml) | 12.2 ± 6.0 | 13.5 ± 5.9 | 11.4 ± 5.9 | 0.003 |
ESR (mm/hour) | 63.3 ± 34.8 | 75.4 ± 34.5 | 56.2 ± 33.0 | <  0.001 |
Osteomyelitis | 91 (27.1) | 59 (64.8) | 32 (35.2) | <  0.001 |
Anemia | 180 (53.6%) | 71 (39.4) | 109 (60.6) | 0.097 |
Renal impairment | 66 (19.6%) | 29 (43.9) | 37 (56.1) | 0.106 |