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Table 1 Demographic, clinical and laboratory characteristics of subjects who underwent lower extremity amputation and those who did not

From: Predictors of lower extremity amputation in patients with diabetic foot ulcer: findings from MEDFUN, a multi-center observational study

Variable Total (n = 336) Amputation P value
Yes No
Age (years) 55.9 ± 12.5 56.8 ± 11.3 55.6 ± 13.1 0.391
Gender (male) 185 (55.1) 67 (36.2) 118 (63.8) 0.734
Diabetes type (type 1) 13 (3.9) 1 (7.7) 12 (92.3) 0.033
Diabetes duration (years) 8.5 ± 5.7 9.1 ± 5.7 8.1 ± 5.7 0.130
Ulcer duration (days) 45.2 ± 41.0 63.9 ± 57.8 35.0 ± 22.1 <  0.001
Ulcer duration (> 1 month) 237 (70.5) 111 (46.8) 126 (53.2) <  0.001
Neuropathy 262 (78.0) 93 (35.5) 169 (64.5) 0.954
PAD 176 (52.4) 87 (49.4) 89 (50.6) <  0.001
Wagner grades
 Grade 1 13 (3.9) 0 (0.0) 13 (100.0)  
 Grade 2 57 (17.0) 3 (5.3) 54 (94.7)  
 Grade 3 88 (26.2) 22 (25.0) 66 (75.0) <  0.001
 Grade 4 124 (36.9) 58 (46.8) 66 (53.2)  
 Grade 5 54 (16.1) 36 (66.7) 18 (33.3)  
Presence of gangrene 178 (53.0) 94 (52.8) 84 (47.2) <  0.001
Wound infection 258 (76.8) 99 (38.4) 159 (61.6) 0.039
Proteinuria 96 (28.6) 54 (44.6) 67 (55.4) 0.021
HbA1c (%) 9.6 ± 1.9 9..9 ± 1.8 9.4 ± 2.0 0.061
White cell count (cells/ml) 12.2 ± 6.0 13.5 ± 5.9 11.4 ± 5.9 0.003
ESR (mm/hour) 63.3 ± 34.8 75.4 ± 34.5 56.2 ± 33.0 <  0.001
Osteomyelitis 91 (27.1) 59 (64.8) 32 (35.2) <  0.001
Anemia 180 (53.6%) 71 (39.4) 109 (60.6) 0.097
Renal impairment 66 (19.6%) 29 (43.9) 37 (56.1) 0.106
  1. Data are in numbers (percentage) or means (± SD)
  2. PAD peripheral artery disease, HbA1c glycated hemoglobin, ESR erythrocyte sedimentation rate