From: The use of urea for the treatment of onychomycosis: a systematic review
 | Bassiri -Jahromi et al. 2012 [30] | Lahfa et al. 2013 [31] | Bunyaratavej at al. 2016 [32] | Fraki et al. 1997 [33] | Escalante et al. 2013 [34] | Baran and Tosti 2002 [35] |
---|---|---|---|---|---|---|
Clinical improvement | Photographs | Judged by investigator | (Scoring Clinical Index for Onychomycosis (SCIO) score). Decrease in thickness of subungual hyperkeratosis from the original untreated nail | Â | Â | Â |
Clinical cure |  | Judged by investigator (>  90% clinical improvement) | Scoring Clinical Index for onychomycosis (SCIO) score (>  90% clinical improvement) | Visual inspection, investigator judgement (>  90% clinical improvement) | Nail dystrophy, thickness and a photographic record |  |
Mycological cure | Fungal culture | Microscopy and fungal culture | Potassium hydroxide and fungal cultures | Microscopy and fungal culture | Potassium hydroxide and fungal cultures | Â |
Complete cure | Â | Mycological cure + clinical cure | Mycological cure + clinical cure | Â | Â | Â |
Adverse events | Participant-reported | Investigator assessment of erythema, irritation, pruritus, desquamation, and patient self-reporting of a burning sensation of the skin surrounding the treated nail (4-point scales) | Â | Â | Participant- reported and clinician driven visual inspection | Participant-reported and clinician driven visual inspection |