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Table 3 Outcome domains and measures

From: The use of urea for the treatment of onychomycosis: a systematic review

  Bassiri -Jahromi et al. 2012 [30] Lahfa et al. 2013 [31] Bunyaratavej at al. 2016 [32] Fraki et al. 1997 [33] Escalante et al. 2013 [34] Baran and Tosti 2002 [35]
Clinical improvement Photographs Judged by investigator (Scoring Clinical Index for Onychomycosis (SCIO) score). Decrease in thickness of subungual hyperkeratosis from the original untreated nail    
Clinical cure   Judged by investigator (>  90% clinical improvement) Scoring Clinical Index for onychomycosis (SCIO) score (>  90% clinical improvement) Visual inspection, investigator judgement (>  90% clinical improvement) Nail dystrophy, thickness and a photographic record  
Mycological cure Fungal culture Microscopy and fungal culture Potassium hydroxide and fungal cultures Microscopy and fungal culture Potassium hydroxide and fungal cultures  
Complete cure   Mycological cure + clinical cure Mycological cure + clinical cure    
Adverse events Participant-reported Investigator assessment of erythema, irritation, pruritus, desquamation, and patient self-reporting of a burning sensation of the skin surrounding the treated nail (4-point scales)    Participant- reported and clinician driven visual inspection Participant-reported and clinician driven visual inspection