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Table 3 Outcome domains and measures

From: The use of urea for the treatment of onychomycosis: a systematic review

 

Bassiri -Jahromi et al. 2012 [30]

Lahfa et al. 2013 [31]

Bunyaratavej at al. 2016 [32]

Fraki et al. 1997 [33]

Escalante et al. 2013 [34]

Baran and Tosti 2002 [35]

Clinical improvement

Photographs

Judged by investigator

(Scoring Clinical Index for Onychomycosis (SCIO) score). Decrease in thickness of subungual hyperkeratosis from the original untreated nail

   

Clinical cure

 

Judged by investigator (>  90% clinical improvement)

Scoring Clinical Index for onychomycosis (SCIO) score (>  90% clinical improvement)

Visual inspection, investigator judgement (>  90% clinical improvement)

Nail dystrophy, thickness and a photographic record

 

Mycological cure

Fungal culture

Microscopy and fungal culture

Potassium hydroxide and fungal cultures

Microscopy and fungal culture

Potassium hydroxide and fungal cultures

 

Complete cure

 

Mycological cure + clinical cure

Mycological cure + clinical cure

   

Adverse events

Participant-reported

Investigator assessment of erythema, irritation, pruritus, desquamation, and patient self-reporting of a burning sensation of the skin surrounding the treated nail (4-point scales)

  

Participant- reported and clinician driven visual inspection

Participant-reported and clinician driven visual inspection