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Table 9 Overview of studies which compared SSI rates in cohorts which received and did not receive antibiotic prophylaxis

From: Antibiotic prophylaxis in foot and ankle surgery: a systematic review of the literature

Study # Participants Incidence of SSI Overview
Antibiotic Prophylaxis No Antibiotic Prophylaxis Study Design Level of Evidence
Butterworth et al. (2017) [18] 4238 1.1% 2.6% Prospective Cohort Study 2++
Mangwani et al. (2016) [27] 100 6.2% 1.9% Prospective RCT 1++
Reyes et al. (1997) [37] 459 0.43% 0.88% Retrospective Cohort Study 3
Zgonis et al. (2004) [22] 555 1.6% 1.4% Retrospective Cohort Study 2+