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Table 4 Outcomes after 8 weeks training to neutral range versus hypermobile range of knee extension

From: Physical and mechanical therapies for lower limb symptoms in children with Hypermobility Spectrum Disorder and Hypermobile Ehlers-Danlos Syndrome: a systematic review

Outcome Neutral range training group (n = 14) Hypermobile range training group (n = 11) Between group differences Cohen’s D
Baseline Mean (SD) 8 weeks Mean (SD) Mean Change Baseline Mean (SD) 8 weeks Mean (SD) Mean Change Mean change difference 95% CI
Child reported knee pain (mean) a 40.04 (16.59) 20.14 (18.37) −19.9 38.55 (16.89) 29.36 (17.99) −9.19 10.71 −7.9 to 29.33 0.61
Child reported knee pain (max)a 57.68 (23.12) 35.64 (28.57) −22.04 53.23 (23.55) 39.18 (27.21) −14.05 7.99 −14.66 to 30.64 0.31
CHAQ Score −0.13 (0.44) −0.01 (0.60) 0.12 0.04 (0.71) 0.05 (0.72) 0.02 0.10 −0.25 to 0.45 0.16
No. flights of stairs/2 min 16.32 (5.00) 20.11 (5.52) 3.79 20.88 (6.69) 20.55 (5.44) −0.33 −4.12 0.301 to − 8.523 0.73
CHQ Physical Summaryc 32.01 (11.86) 42.08 (10.81) 10.07 41.61 (14.96) 43.91 (15.05) 2.3 −7.77 −14.99 to -.055b 0.59
CHQ Psychosocial Summaryc 46.35 (12.26) 45.41 (13.49) −0.94 46.29 (8.95) 54.41 (4.42) 8.12 9.06 2.66 to 15.47b 0.83
  1. aUsing 100 mm VAS Scale; bstatistically significant, cA difference of 7 or more points indicates a clinically significant difference [47].CHAQ: Child Health Assessment Questionnaire, N Newtons. CHQ: Child Health Questionnaire. Lower score desirable for all outcomes but number of flight of stairs/2 min and CHQ summaries