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Table 1 Demographics and clinical characteristics of the patients with diabetes and infectious foot gangrene and risk factors for mortality in a Cox proportional hazards model (Total number: 157)

From: Survival and associated risk factors in patients with diabetes and amputations caused by infectious foot gangrene

Characteristic Mean (standard deviation) or Number (%) Multivariate+ analysis
Mortality HR (95% CI) P value
Age (years) 66.8 (±10.8) 1.04*(1.01–1.06) 0.01
Gender     0.37
 Female 58 (36.9%) 1  
 Male 99 (63.1%) 0.79 (0.46–1.33)  
Diabetes duration (years) 12.8 (±8.4) 1.14 (0.92–1.43) 0.24
Smoking status 34 (21.7%) 1.48 (0.73–3.01) 0.28
Hypertension 111 (70.7%) 1.06 (0.63–1.80) 0.83
Major adverse cardiac events 52 (33.1%) 1.48 (0.88–2.50) 0.14
Abnormal ABI 104 (66.2%) 1.28 (0.67–2.42) 0.46
Renal function
 Normal renal function (eGFR ≥60) 58 (36.9%) 1  
 Chronic kidney disease (eGFR <60) 59 (37.6%) 0.87 (0.48–1.59) 0.66
 Dialysis 40 (25.5%) 2.09^(0.99–4.41) 0.05
HbA1c (%) 9.4 (±2.7) 1.02 (0.92–1.13) 0.71
Limb amputation status
 Minor LEA 67 (42.7%) 1  
 Major LEA 90 (57.3%) 1.80*(1.05–3.09) 0.03
  1. *Significance: P value <0.05
  2. ^Borderline significance: P value = 0.05
  3. +Including continuous variables of age, diabetes duration, and HbA1c; and categorical variables of gender, smoking status, hypertension, major adverse cardiac events, ankle-brachial index, renal function and LEA status
  4. HR hazard ratio, ABI ankle-brachial index, eGFR estimated glomerular filtration rate, LEA lower-extremity amputation