Table 3 Inclusion and Exclusion Criteria

Study design

• Full-text available in English

• Cohort studies (retrospective/prospective)

• Non-English

• Case reports, commentaries, reviews

Population (P)

• Human

• Chronic limb ischaemia with tissue loss (Fontaine IV or Rutherford 5, 6)

• Studies of interventions in patients with diabetes

• Cadaver or animal

• Acute limb ischaemia

• Chronic limb ischaemia without tissue loss (e.g. rest pain only; Fontaine III or Rutherford 4)

• Mixed cohorts (i.e. not all patients have diabetes)

Intervention (I), Comparison (C)

• Arterial revascularisations

• Revascularisation with application of the angiosome concept

• Comparative study of DR and IR

• Non-arterial revascularisations

• Revascularisation without application of the angiosome concept

• Non-comparative studies of DR and IR

Outcome (O)

• Studies which utilised wound healing as an outcome measure

• Studies where wound healing was not utilised as an outcome measure