Fig. 4

Plasma TNF-α (pg/ml) in Charcot patients (n = 28), diabetes control patients (n = 20) and healthy donors (n = 20). §P = 0.005 for diabetic controls versus healthy, §§P = 0.005 for diabetic controls versus Charcot. Difference between Charcot at inclusion and diabetic controls was not significant (p = 0.64). *P = 0.02 for Charcot at 4 months versus Charcot at inclusion. +P = 0.001 for diabetic controls versus healthy, ++P = 0.015 for diabetic controls versus Charcot. Difference between Charcot and healthy at 2 years was not significant (p = 0.53). Charcot at 2 years was not different from Charcot at inclusion (p = 0.44). Mean ± SEM