Table 1 Clinical and demographic data in Charcot patients, diabetic controls and healthy subjects

Age (median- range, years)

61 (42–87)

63 (42–87)

55 (20–94)

57 (20–94)

58 (24–78)

Gender (n)

 Females

10

10

8

8

9

 Males

16

16

12

12

11

Diabetes type 1/2 (n)

11/15

11/15

6/14

6/14

-

Diabetes duration (years)

25 ± 4

-

14 ± 6

-

-

Debut foot symptoms (weeks, median-range)

8.4 (1–24)

-

-

-

-

Systolic blood pressure (mmHg)

149 ± 6

148 ± 6

127 ± 4

-

138 ± 4

Diastolic blood pressure (mmHg)

80 ± 3

80 ± 3

76 ± 2

-

81 ± 3

Arterial toe pressure (mmHg)

 Charcot foot

114 ± 11

122 ± 8

115 ± 4

-

-

 Contralateral foot

129 ± 8

119 ± 7

114 ± 5

-

-

Skin temperature (°C)

 Charcot foot

31.3 ± 0.8^a

29.7 ± 0.7

30,0 ± 0,4

-

-

 Contralateral foot

28.8 ± 0.9

29.3 ± 0.7

30,2 ± 0,4

-

-

Pain at rest (n)

4

0

0

-

-

Pain at weight bearing (n)

17

0

0

-

-

Foot distorsion (n)

4

4

0

-

0

Total contact cast (months)

-

7.7 ± 1.0

-

-

-

Charcot pattern I/II/III/IV/V (n)

2/16/5/0/3

-

-

-

-

Nephropathy/Cardiac disease (n)

7/4

7/4

2/1

2/1

0/0

 Hb (g/L)

127 ± 3

129 ± 3

136 ± 2

139 ± 3

143 ± 5

 S-CRP (mg/L)

10.6 ± 3^b,c

10.0 ± 2^d,e

3.6 ± 0,8

3.8 ± 0,8

2.7 ± 0,7

 SR (mm)

28.8 ± 6^f,g

23 ± 5

11 ± 2

10 ± 2

6 ± 4

 S-Kreatinin (μmol/L)

112 ± 19

101 ± 12

83 ± 8

89 ± 7

78 ± 5

 HbA1c (mmol/mol)

60 ± 3

64 ± 2

58 ± 3

56 ± 2

-

 HbA1c (%)

7.8 ± 0.3

7.4 ± 0.3

7.5 ± 0.2

7.3 ± 0.2

-