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Table 1 Clinical and demographic data in Charcot patients, diabetic controls and healthy subjects

From: IL-17 cytokines in bone healing of diabetic Charcot arthropathy patients: a prospective 2 year follow-up study

  Charcot arthropathy Inclusion Charcot arthropathy End of study Diabetic controls Inclusion Diabetic controls +2Y Healthy subjects
(n = 26) (n = 26) (n = 20) (n = 20) (n = 20)
Age (median- range, years) 61 (42–87) 63 (42–87) 55 (20–94) 57 (20–94) 58 (24–78)
Gender (n)      
 Females 10 10 8 8 9
 Males 16 16 12 12 11
Diabetes type 1/2 (n) 11/15 11/15 6/14 6/14 -
Diabetes duration (years) 25 ± 4 - 14 ± 6 - -
Debut foot symptoms (weeks, median-range) 8.4 (1–24) - - - -
Systolic blood pressure (mmHg) 149 ± 6 148 ± 6 127 ± 4 - 138 ± 4
Diastolic blood pressure (mmHg) 80 ± 3 80 ± 3 76 ± 2 - 81 ± 3
Arterial toe pressure (mmHg)      
 Charcot foot 114 ± 11 122 ± 8 115 ± 4 - -
 Contralateral foot 129 ± 8 119 ± 7 114 ± 5 - -
Skin temperature (°C)      
 Charcot foot 31.3 ± 0.8a 29.7 ± 0.7 30,0 ± 0,4 - -
 Contralateral foot 28.8 ± 0.9 29.3 ± 0.7 30,2 ± 0,4 - -
Pain at rest (n) 4 0 0 - -
Pain at weight bearing (n) 17 0 0 - -
Foot distorsion (n) 4 4 0 - 0
Total contact cast (months) - 7.7 ± 1.0 - - -
Charcot pattern I/II/III/IV/V (n) 2/16/5/0/3 - - - -
Nephropathy/Cardiac disease (n) 7/4 7/4 2/1 2/1 0/0
 Hb (g/L) 127 ± 3 129 ± 3 136 ± 2 139 ± 3 143 ± 5
 S-CRP (mg/L) 10.6 ± 3b,c 10.0 ± 2d,e 3.6 ± 0,8 3.8 ± 0,8 2.7 ± 0,7
 SR (mm) 28.8 ± 6f,g 23 ± 5 11 ± 2 10 ± 2 6 ± 4
 S-Kreatinin (μmol/L) 112 ± 19 101 ± 12 83 ± 8 89 ± 7 78 ± 5
 HbA1c (mmol/mol) 60 ± 3 64 ± 2 58 ± 3 56 ± 2 -
 HbA1c (%) 7.8 ± 0.3 7.4 ± 0.3 7.5 ± 0.2 7.3 ± 0.2 -
  1. Mean ± SEM when not given differently. ap = 0.010 Charcot foot versus contralateral foot at inclusion. bp = 0.044 for Charcot at inclusion versus diabetic controls at inclusion.cp = 0.012 for Charcot at inclusion versus healthy. dp = 0.038 Charcot end of study vs diabetic controls +2y. ep = 0.022 Charcot end of study vs healthy. fp = 0.001 Charcot at inclusion versus diabetic controls at inclusion. gp < 0.001 for Charcot at inclusion versus healthy. All other differences are not significant. Charcot pattern I-V on radiographs as described by Sanders and Frykberg (see ref: Papanas and Maltezos, 2013 [17])