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Table 2 Summary of primary outcome measures by data of multiple imputation

From: Efficacy of intraarticular botulinum toxin A and intraarticular hyaluronate plus rehabilitation exercise in patients with unilateral ankle osteoarthritis: a randomized controlled trial

Outcome Baseline 2 weeks 1 month 3 months 6 months
  BoNT-A HA BoNT-A HA BoNT-A HA BoNT-A HA BoNT-A HA
Total AOSa 4.9 ± 1.5 4.7 ± 1.0 2.7 ± 1.3 3.0 ± 1.3 2.5 ± 1.4 2.6 ± 1.2 2.5 ± 1.4 2.6 ± 1.2 2.6 ± 1.2 2.7 ± 1.0
A.M.D. (95% CI)    -0.3 (-0.8, 0.2) -0.2 (-0.5, 0.2) -0.2 (-0.6, 0.2) -0.2 (-0.5, 0.2)
p b    0.18 0.41 0.30 0.39
Pain subscalea 4.5 ± 1.3 4.5 ± 1.1 2.5 ± 1.2 2.8 ± 1.3 2.3 ± 1.4 2.3 ± 1.0 2.3 ± 1.4 2.4 ± 1.1 2.4 ± 1.2 2.5 ± 1.1
A.M.D. (95% CI)    -0.3 (-0.8, 0.2) -0.04 (-0.4, 0.3) -0.2 (-0.6, 0.2) -0.1 (-0.5, 0.3)
p b    0.24 0.85 0.42 0.57
Disability subscalea 5.2 ± 1.9 5.0 ± 1.3 3.0 ± 1.5 3.2 ± 1.4 2.8 ± 1.5 2.9 ± 1.7 2.8 ± 1.5 2.8 ± 1.4 2.9 ± 1.3 2.9 ± 1.1
A.M.D. (95% CI)    -0.3 (-0.8, 0.2) -0.3 (-0.7, 0.2) -0.2 (-0.7, 0.2) -0.2 (-0.6, 0.2)
p b    0.18 0.23 0.31 0.36
  1. NOTE: Values are the mean ± standard deviation; BoNT-A = Botulinum toxin type A; HA = Hyaluronate; AOS = Ankle Osteoarthritis Scale; A.M.D. = Adjusted mean difference; CI = Confidence interval.
  2. aHigher scores represent worse pain or function.
  3. bANCOVA for comparing two groups in each posttest.
  4. The primary endpoint was 6 months.