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Table 2 Summary of primary outcome measures by data of multiple imputation

From: Efficacy of intraarticular botulinum toxin A and intraarticular hyaluronate plus rehabilitation exercise in patients with unilateral ankle osteoarthritis: a randomized controlled trial

Outcome

Baseline

2 weeks

1 month

3 months

6 months

 

BoNT-A

HA

BoNT-A

HA

BoNT-A

HA

BoNT-A

HA

BoNT-A

HA

Total AOSa

4.9 ± 1.5

4.7 ± 1.0

2.7 ± 1.3

3.0 ± 1.3

2.5 ± 1.4

2.6 ± 1.2

2.5 ± 1.4

2.6 ± 1.2

2.6 ± 1.2

2.7 ± 1.0

A.M.D. (95% CI)

  

-0.3 (-0.8, 0.2)

-0.2 (-0.5, 0.2)

-0.2 (-0.6, 0.2)

-0.2 (-0.5, 0.2)

p b

  

0.18

0.41

0.30

0.39

Pain subscalea

4.5 ± 1.3

4.5 ± 1.1

2.5 ± 1.2

2.8 ± 1.3

2.3 ± 1.4

2.3 ± 1.0

2.3 ± 1.4

2.4 ± 1.1

2.4 ± 1.2

2.5 ± 1.1

A.M.D. (95% CI)

  

-0.3 (-0.8, 0.2)

-0.04 (-0.4, 0.3)

-0.2 (-0.6, 0.2)

-0.1 (-0.5, 0.3)

p b

  

0.24

0.85

0.42

0.57

Disability subscalea

5.2 ± 1.9

5.0 ± 1.3

3.0 ± 1.5

3.2 ± 1.4

2.8 ± 1.5

2.9 ± 1.7

2.8 ± 1.5

2.8 ± 1.4

2.9 ± 1.3

2.9 ± 1.1

A.M.D. (95% CI)

  

-0.3 (-0.8, 0.2)

-0.3 (-0.7, 0.2)

-0.2 (-0.7, 0.2)

-0.2 (-0.6, 0.2)

p b

  

0.18

0.23

0.31

0.36

  1. NOTE: Values are the mean ± standard deviation; BoNT-A = Botulinum toxin type A; HA = Hyaluronate; AOS = Ankle Osteoarthritis Scale; A.M.D. = Adjusted mean difference; CI = Confidence interval.
  2. aHigher scores represent worse pain or function.
  3. bANCOVA for comparing two groups in each posttest.
  4. The primary endpoint was 6 months.