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Table 1 NHMRC levels of evidence

From: Developing an evidence-based clinical pathway for the assessment, diagnosis and management of acute Charcot Neuro-Arthropathy: a systematic review

Level of evidence Definition
I A systematic review of level II studies
II A randomised controlled trial
III A pseudorandomised controlled trial (i.e. alternate allocation or some other method)
III-2 A comparative study with concurrent controls (i.e. non-randomised experimental trial, cohort study, case–control study)
III-3 A comparative study without concurrent controls (i.e. historical cohort study, two or more single arm study)
IV Case series
EO Expert opinion – where evidence was absent or unreliable and advice was formulated based on the clinical judgement and experience of experts in the field